Effect of gastric acid-suppressive therapy and biological variation of serum gastrin concentrations in dogs with chronic enteropathies

Heilmann, Romy M.; Berghoff, Nora; Grützner, Niels; Parnell, Nolie K.; Suchodolski, Jan S.; Steiner, Jörg M.

doi:10.1186/s12917-017-1233-y

Table 3 Correlation of serum gastrin with variables of the histologic score for canine CE

From: Effect of gastric acid-suppressive therapy and biological variation of serum gastrin concentrations in dogs with chronic enteropathies

Histologic findings		serum gastrin concentration (ng/L)
Histologic findings	N	Spearman ρ	unadjusted P ^†	adjusted P ^#
Stomach (composite score)	97	−0.1291	0.2075	0.4150
Fundus: Morphologic criteria (sum)	92	0.0885	0.4014	ns
- Surface epithelial injury	92	0.0517	0.6248	ns
- Gastric pit epithelial injury	92	0.0151	0.8866	ns
- Mucosal fibrosis	92	0.0167	0.8741	ns
Fundus: Inflammatory criteria (sum)	92	−0.0902	0.3923	ns
- Intraepithelial lymphocytes	92	−0.0434	0.6815	ns
- Lamina propria LPC	92	−0.1358	0.1966	ns
- Lamina propria eosinophils	92	0.0408	0.6993	ns
- Lamina propria neutrophils	92	−0.0938	0.3740	ns
- Lamina propria macrophages	92	−0.0938	0.3740	ns
- Lymphoid follicular hyperplasia	92	0.0079	0.9401	ns
Antrum: Morphologic criteria (sum)	86	0.0299	0.7844	ns
- Surface epithelial injury	86	0.3241	*0.0023*	*0.0069*
- Gastric pit epithelial injury	86	−0.1258	0.2483	ns
- Mucosal fibrosis	86	−0.0968	0.3754	ns
Antrum: Inflammatory criteria (sum)	86	−0.1489	0.1737	0.6948
- Intraepithelial lymphocytes	86	−0.0474	0.6650	ns
- Lamina propria LPC	86	−0.1969	0.0691	0.4146
- Lamina propria eosinophils	86	0.0140	0.8990	ns
- Lamina propria neutrophils	86	−0.1933	0.0745	0.4470
- Lamina propria macrophages	86	−0.0651	0.5512	ns
- Lymphoid follicular hyperplasia	86	−0.0815	0.4557	ns
Duodenum (composite score)	100	0.2108	*0.0362*	0.0724
Morphologic criteria (sum)	100	0.1178	0.2432	0.4864
- Villus stunting	100	0.1130	0.2629	ns
- Epithelial injury	100	0.0452	0.6554	ns
- Crypt distension	100	0.0966	0.3391	ns
- Lacteal dilation	100	0.1320	0.1906	0.9530
- Mucosal fibrosis	100	−0.0467	0.6444	ns
Inflammatory criteria (sum)	100	0.1239	0.2218	0.4436
- Intraepithelial lymphocytes	100	−0.0877	0.3855	ns
- Lamina propria LPC	100	0.0680	0.5013	ns
- Lamina propria eosinophils	100	0.1927	0.0560	0.2800
- Lamina propria neutrophils	100	0.1096	0.2779	ns
- Lamina propria macrophages	100	0.0663	0.5121	ns

Relationship between serum gastrin concentrations and the severity of morphologic and inflammatory histologic lesions of the stomach and duodenum in dogs with CE (n = 102)
CE chronic enteropathy, LPC lymphocytes/plasma cells, N sample size, ns non-significant with P = 1.0000; ^†without correction (P < 0.05); ^#after Holm-Bonferroni correction (n = 2, 4, or 5)
P values in boldface and italicized indicate significance at P < 0.05

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