An optimized swine dysentery murine model to characterize shedding and clinical disease associated with “Brachyspira hampsonii” infection

Table 2 Summarized pathologic lesion results from Experiment 2 evaluating mouse strain^a

				Colon			Caecum
Mouse strain	Species Group	Presence of soft mucoid faeces	Mean faecal consistency score^b	Catarrhal inflammation	Neutrophilic infiltration	Epithelial regeneration	Catarrhal inflammation	Neutrophilic infiltration	Epithelial regeneration
CF-1	Ctrl	0/4	0.031	2/4	0/4	0/4	0/4	0/4	0/4
C3H	Ctrl	0/4	0.000	2/4	0/4	0/4	0/4	0/4	0/4
CF-1	Bhamp	3/4	0.988	3/4	2/4	3/4	1/4	0/4	3/4
C3H	Bhamp	1/5	0.113	2/5	2/5	2/5	4/5	2/5	2/5

Legend: Ctrl non-inoculated group, Bhamp “B. hampsonii” inoculated group, CF-1 CF-1 mouse strain, C3H C3H mouse strain. See Additional files 1, 2, 3, 4 and 5 for description of histopathologic lesion scores
^aValues indicate the numbers (proportions) of mice with each type of clinical sign or lesion
^bMean fecal consistency score calculated by averaging twice daily observations from 3 dpi to termination. Mean fecal score differs across mouse strain: CF-1 vs C3H (P = 0.049)

ISSN: 1746-6148