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Table 2 Pharmacokinetic parameters for prednisone, 20α-dihydroprednisolone and 20β-dihydroprednisolone after intramuscular administration during therapeutic prednisolone treatment

From: Pharmacokinetic and urinary profiling reveals the prednisolone/cortisol ratio as a valid biomarker for prednisolone administration

 

Prednisone

20α-dihydroprednisolone

20β-dihydroprednisolone

Cmax (μg L−1)

13.3 ± 2.56

1.64 ± 0.677

19.2 ± 4.31

Tmax (h)

0.857 ± 0.136

1.42 ± 0.413

2.17 ± 0.571

AUC0-inf (h μg L−1)

58.5 ± 12.1

7.07 ± 3.33

121 ± 26.9

kel (h−1)

0.307 ± 0.101

0.553 ± 0.184

0.349 ± 0.086

T1/2el (h)

2.43 ± 0.649

1.53 ± 1.02

2.09 ± 0.522

  1. Average parameter values and SD were determined on the basis of 12 samples. Intramuscular therapeutic treatment concerned the injection of 0.5 mg prednisolone kg−1 day−1
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BMC Veterinary Research

ISSN: 1746-6148

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