Skip to main content

Table 2 Pharmacokinetic parameters for prednisone, 20α-dihydroprednisolone and 20β-dihydroprednisolone after intramuscular administration during therapeutic prednisolone treatment

From: Pharmacokinetic and urinary profiling reveals the prednisolone/cortisol ratio as a valid biomarker for prednisolone administration

  Prednisone 20α-dihydroprednisolone 20β-dihydroprednisolone
Cmax (μg L−1) 13.3 ± 2.56 1.64 ± 0.677 19.2 ± 4.31
Tmax (h) 0.857 ± 0.136 1.42 ± 0.413 2.17 ± 0.571
AUC0-inf (h μg L−1) 58.5 ± 12.1 7.07 ± 3.33 121 ± 26.9
kel (h−1) 0.307 ± 0.101 0.553 ± 0.184 0.349 ± 0.086
T1/2el (h) 2.43 ± 0.649 1.53 ± 1.02 2.09 ± 0.522
  1. Average parameter values and SD were determined on the basis of 12 samples. Intramuscular therapeutic treatment concerned the injection of 0.5 mg prednisolone kg−1 day−1