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Table 1 Pharmacokinetic parameters for metoclopramide, ondansetron and maropitant after IV administration

From: Anti-nausea effects and pharmacokinetics of ondansetron, maropitant and metoclopramide in a low-dose cisplatin model of nausea and vomiting in the dog: a blinded crossover study

Parameter Units Ondansetron
(n = 8)
Maropitant
(n = 8)
Metoclopramide
(n = 7)
Cmax μg/L 186.8 ± 60.6 247.0 ± 86.2 113.2 ± 22.4
t1/2 h 1.21 ± 0.51 5.62 ± 0.77 0.87 ± 0.17
AUC0-last μg/L/h 176.4 ± 32.6 705.2 ± 236 111.9 ± 27.2
Cl L/kg/h 2.90 ± 0.43 1.57 ± 0.53 4.72 ± 1.25
MRT h 1.15 ± 0.43 6.68 ± 1.30 1.04 ± 0.16
  1. Legend: All results are presented as the arithmetic mean ± SD except t1/2 which is presents as the harmonic mean ± Pseudo SD