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Table 4 Mean and 95% posterior credible intervals (PCI) for the sensitivity (Se) and specificity (Sp) of two serum ELISAs and one fecal qPCR, depending on different scenarios

From: Estimation of the sensitivity and specificity of two serum ELISAs and one fecal qPCR for diagnosis of paratuberculosis in sub-clinically infected young-adult French sheep using latent class Bayesian modeling

Dataset   Mean (95% PCI)
Se Sp
Doubtful ELISA results as negative, fecal qPCR cut-off Ct ≤ 42 ELISA A 17.3 (11.0; 24.8) 95.3 (93.7; 96.7)
ELISA B 14.7 (8.5; 22.4) 95.6 (94.0; 97.0)
Fecal qPCR 50.9 (31.3; 73.3) 99.2 (98.2; 99.8)
Doubtful ELISA results as positive, fecal qPCR cut-off Ct ≤ 40 ELISA A 21.0 (12.8; 30.8) 94.8 (93.1; 96.3)
ELISA B 20.0 (11.9; 30.2) 94.0 (92.2; 95.6)
Fecal qPCR 40.7 (23.5; 63.2) 99.0 (98.0; 99.7)
Doubtful ELISA results as negative, fecal qPCR cut-off Ct ≤ 40 ELISA A 21.2 (12.9; 31.0) 95.3 (93.7; 96.7)
ELISA B 17.4 (9.5; 27.5) 95.5 (94.0; 96.9)
Fecal qPCR 45.8 (26.2; 69.3) 99.2 (98.2; 99.8)
  1. Estimates were obtained with model 1