Estimation of the sensitivity and specificity of two serum ELISAs and one fecal qPCR for diagnosis of paratuberculosis in sub-clinically infected young-adult French sheep using latent class Bayesian modeling

Table 4 Mean and 95% posterior credible intervals (PCI) for the sensitivity (Se) and specificity (Sp) of two serum ELISAs and one fecal qPCR, depending on different scenarios

Dataset		Mean (95% PCI)
Dataset		Se	Sp
Doubtful ELISA results as negative, fecal qPCR cut-off Ct ≤ 42	ELISA A	17.3 (11.0; 24.8)	95.3 (93.7; 96.7)
	ELISA B	14.7 (8.5; 22.4)	95.6 (94.0; 97.0)
	Fecal qPCR	50.9 (31.3; 73.3)	99.2 (98.2; 99.8)
Doubtful ELISA results as positive, fecal qPCR cut-off Ct ≤ 40	ELISA A	21.0 (12.8; 30.8)	94.8 (93.1; 96.3)
	ELISA B	20.0 (11.9; 30.2)	94.0 (92.2; 95.6)
	Fecal qPCR	40.7 (23.5; 63.2)	99.0 (98.0; 99.7)
Doubtful ELISA results as negative, fecal qPCR cut-off Ct ≤ 40	ELISA A	21.2 (12.9; 31.0)	95.3 (93.7; 96.7)
	ELISA B	17.4 (9.5; 27.5)	95.5 (94.0; 96.9)
	Fecal qPCR	45.8 (26.2; 69.3)	99.2 (98.2; 99.8)

ISSN: 1746-6148