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Table 3 Mean and 95% posterior credible intervals (PCI) for the sensitivity (Se) and specificity (Sp) of two serum ELISAs and on fecal qPCR and true prevalence (Ps) of MAP in sub-populations 1 to 4

From: Estimation of the sensitivity and specificity of two serum ELISAs and one fecal qPCR for diagnosis of paratuberculosis in sub-clinically infected young-adult French sheep using latent class Bayesian modeling

   Mean (95% PCI)
   Model 1a Model 2b Model 3c
DIC   120.4 134.2 227.9
ELISA A Se 17.9 (11.4; 25.6) 19.7 (13.1; 27.3) 70.0 (56.0; 85.6)
  Sp 94.8 (93.1; 96.3) 95.0 (93.4; 96.5) 98.7 (97.4; 99.9)
ELISA B Se 17.4 (10.6; 25.9) 23.2 (15.8; 31.5) 80.0 (63.7; 95.3)
  Sp 94.0 (92.2; 95.7) 94.8 (93.2; 96.4) 98.9 (97.5; 99.9)
Fecal qPCR Se 47.5 (29.3; 69.9) 56.3 (36.9; 77.3) 31.3 (21.8; 41.9)
  Sp 99.0 (97.9; 99.7) 99.4 (98.4; 99.9) 93.2 (91.6; 94.7)
Sub-pop. 1 P1 0.01 (0.0; 0.03) 1.2 (0.1; 3.8) 6.6 (3.1; 11.0)
Sub-pop. 2 P2 5.4 (1.6; 11.5) 6.2 (2.5; 11.9) 8.1 (4.7; 12.3)
Sub-pop. 3 P3 21.7 (13.1; 34.5) 19.2 (12.1; 29.4) 8.4 (5.2; 12.3)
Sub-pop. 4 P4 57.3 (35.4; 88.8) 47.2 (31.0; 70.4) 15.5 (9.7; 22.6)
ΔELISA A – ELISA B Se 0.5 (−5.6; 5.9) −3.5 (−9.9; 2.5) −10.0 (−28.8; 9.3)
  Sp 0.8 (−0.8; 2.4) 0.2 (−1.2; 1.5) −0.2 (−1.9; 1.5)
ΔFecal PCR – ELISA A Se 29.6 (13.7; 50.9) 36.7 (18.6; 57.9) −38.8 (−56.4; −22.4)
  Sp 4.2 (2.5; 6.0) 4.4 (2.6; 6.2) −5.5 (−7.4; −3.7)
Δ Fecal PCR – ELISA B Se 30.1 (14.5; 50.8) 33.1 (16.0; 53.4) −48.8 (−66.4; −30.8)
  Sp 5.0 (3.4; 6.7) 4.6 (2.8; 6.4) −5.7 (−7.7; −3.8)
  1. Doubtful ELISA and fecal qPCR Ct ≤ 42 results were treated as positive
  2. aModels with pairwise dependence between ELISA A and ELISA B for sensitivity and pairwise dependence between the three tests for specificity
  3. bModels with pairwise dependence between ELISA A and ELISA B for sensitivity and specificity and assuming conditional independence of fecal qPCR
  4. cModels assuming fully conditional independence between the three tests