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Fig. 4 | BMC Veterinary Research

Fig. 4

From: Prediction of marbofloxacin dosage for the pig pneumonia pathogens Actinobacillus pleuropneumoniae and Pasteurella multocida by pharmacokinetic/pharmacodynamic modelling

Fig. 4

Formulae for calculation of the loading dose for 48 h duration of action, where eq. a can be expressed as eq. b and simplified as eq. c. K10 = elimination rate constant; τ = dosing interval in h; Cl48 = body clearance over 48 h; KPD breakpoint = AUC divided by 24; MICDistribution = MICs determined from epidemiological surveys; F = bioavailability (from 0 to 1); fu = fraction of drug not bound to protein binding

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BMC Veterinary Research

ISSN: 1746-6148

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