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Table 2 Rotational thromboelastometry and platelet function analysis closure time prior to (T0), and at 5 (T5), 60 (T60) and 120 (T120) minutes after administration of mannitol and hypertonic saline (HTS)

From: Comparison of the effects of 7.2% hypertonic saline and 20% mannitol on whole blood coagulation and platelet function in dogs with suspected intracranial hypertension - a pilot study

Variable

Time point

Osmotherapeutic solution and sample size

Mannitol

Sample size

HTS

Sample size

CtPFA

(RI: 42-90s)

T0

76 (72-86)

15

90 (75-102)

13

T5

96 (79-127)

15

96 (77-138)

13

T60

85 (76-96)

11

98 (70-113)

12

T120

79 (75-83)

8

78 (71-118)

11

EXTEM® CT

(RI: 20-85 s)

T0

42 (37-50)

15

42 (35-54)

15

T5

41 (32-45)

15

38 (35-50)

15

T60

38 (36-49)

11

40 (34-45)

12

T120

43 (29-46)

9

41 (36-49)

11

EXTEM® CFT

(RI: 55-374 s)

T0

84 (59-129)

14

93 (86-111)

15

T5

114 (74-145)

14

115 (102-124)

14

T60

97 (68-105)

10

115 (99-190)

12

T120

98 (77-125)

8

108 (93-147)

11

EXTEM® A10

(RI: 17-69 mm)

T0

58 (46-62)

15

54 (49-61)

15

T5

56 (46-58)

15

51 (39-61)

14

T60

57 (53-67)

11

54 (53-67)

12

T120

60 (52-63)

9

55 (44-56)

11

EXTEM® α-angle

(RI: 57-86°)

T0

73 (61-81)

14

72 (69-75)

15

T5

76 (65-71)

14

67 (64-71)

14

T60

72 (69-79)

10

69 (64-77)

12

T120

69 (65-81)

8

70 (65-75)

11

EXTEM® MCF

(RI: 29-75 mm)

T0

68 (52-69)

15

66 (59-69)

15

T5

65 (51-67)*

15

62 (51-67)

14

T60

67 (64-74)

11

63 (50-67)

12

T120

68 (61-71)

9

63 (58-65)

11

FIBTEM® CT

(RI: 18-72 s)

T0

38 (31-44)

15

42 (36-46)

14

T5

36 (32-44)

15

33 (32-39)*

14

T60

39 (33-50)

11

35 (30-36)*

11

T120

40 (32-44)

9

35 (36-42)*

10

FIBTEM® A10

(RI: 2-17 mm)

T0

12 (10-21)

15

11 (6-15)

14

T5

11 (10-17)

15

10 (7-13)

14

T60

14 (10-21)

11

10 (9-15)

11

T120

16 (11-17)

9

11 (8-15)

10

FIBTEM® α-angle

(RI: 61-88°)

T0

75 (65-79)

13

67 (65-74)

10

T5

75 (67-81)

11

72 (70-75)

10

T60

77 (74-79)

8

67 (62-76)

8

T120

76 (64-78)

8

72 (61-77)

6

FIBTEM® MCF

(RI: 3-17 mm)

T0

14 (9-20)

15

12 (7-16)

14

T5

13 (9-19)*

15

11 (8-13)

13

T60

14 (9-18)*

11

10 (9-15)

11

T120

15 (13-18)

9

12 (9-15)

10

  1. Ct PFA platelet closure time, CT clotting time, CFT clot formation time, A10 clot firmness amplitude 10 min after CT, MCF maximal clot firmness; variables are shown as median (interquartile range), RI institutional reference intervals; bold font, median value outside of the RI; *, significant different to T0 (P < 0.05)
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BMC Veterinary Research

ISSN: 1746-6148

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