Table 1 Pharmakokinetic parameters of imepitoin in healthy cats
From: Imepitoin is well tolerated in healthy and epileptic cats
Day | |||||||||
|---|---|---|---|---|---|---|---|---|---|
1 | 14 | 29 | |||||||
Cmax | AUClast | Tmax | Cmax | AUClast | Tmax | Cmax | AUClast | Tmax | |
Dose 30 mg/kg | 9990 | 39,640 | 3.0 | 2940 | 11,720 | 1.0 | 1590 | 6932 | 3.0 |
5180 | 35,870 | 1.0 | 1840 | 7615 | 1.0 | 5600 | 47,560 | 1.0 | |
5980 | 46,780 | 3.0 | 1910 | 9726 | 0.5 | 934 | 4242 | 0.5 | |
7220 | 35,030 | 3.0 | 4380 | 9883 | 1.0 | 1400 | 4115 | 0.5 | |
6830 | 47,970 | 1.0 | 6540 | 22,620 | 1.0 | 6300 | 26,190 | 1.0 | |
5880 | 35,790 | 3.0 | 3240 | 15,850 | 1.0 | 7500 | 20,800 | 1.0 | |
N | 6 | 6 | 6 | 6 | 6 | 6 | 6 | 6 | 6 |
Mean | 6850 | 40,200 | 2.3 | 3480 | 12,900 | 0.92 | 3890 | 18,300 | 1.2 |
SD | 1700 | 5810 | 1.0 | 1770 | 5510 | 0.20 | 2900 | 17,000 | 0.93 |