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Table 2 Spearman’s rank correlation coefficients between synovial fluid and serum pain mediators and clinical variables of osteoarthritic pain

From: The effect of intra-articular botulinum toxin A on substance P, prostaglandin E2, and tumor necrosis factor alpha in the canine osteoarthritic joint

Variable SF PGE2 Serum PGE2 SF SP Serum SP PVF VI HCPI Pain on palpation
SF PGE2 1.00 0.23 0.10 −0.05 −0.62* −0.61* 0.05 0.45*
Serum PGE2 0.23 1.00 −0.11 −0.48* 0.03 0.04 −0.08 −0.14
SF SP 0.10 −0.11 1.00 0.09 −0.02 0.02 0.02 −0.09
Serum SP −0.05 −0.48* 0.09 1.00 0.12 0.10 −0.03 −0.04
  1. SF synovial fluid, PGE 2 prostaglandin E2, SP substance P, PVF peak vertical force, VI vertical impulse, HCPI Helsinki Chronic Pain Index, Pain on palpation = subjective evaluation of pain on palpation of the joint. *P < 0.05