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Table 2 Clinical and post mortem data of Fischer 344 rats (6 rats/groups) infected with Francisella tularensis ssp. holarctica

From: Comparison of virulence of Francisella tularensis ssp. holarctica genotypes B.12 and B.FTNF002-00

Strain Infectious dose Clinical signa Total weight loss (%) Day of deathb Seroconversion Amount of antigen (IHC)c
B.12 100 CFU mild 0 E + low
0 E + minimal
2.5 E + none
3.5 E + none
severe 7.3 E + low
24 10 - high
101 CFU mild 0 E + minimal
0 E + low
3 E + minimal
10.6 E + minimal
moderate 3.6 E + minimal
severe 18.1 8 - high
102 CFU mild 0 E + minimal
3.7 E + none
7 E + minimal
17.6 E + minimal
moderate 4.6 E + low
13.6 E + minimal
B.FTNF002-00 100 CFU mild 0 E + none
3.1 E + none
14.4 E + minimal
severe 5.6 7 - high
11.4 8 - high
35.5 12 - high
101 CFU mild 5.7 E + none
11.4 E + none
moderate 9 E + low
severe 12.4 7 - moderate
16.5 E + low
21.5 9 - moderate
102 CFU mild 4.8 E + none
6.3 E + none
moderate 7.7 E + minimal
9.3 E + low
19.3 E + none
severe 12.3 4 - high
  1. aThe most severe clinical sign shown during the experiment
  2. bDay of death after injection; E: euthanized on day 21 post infection
  3. cDuring the immunohistochemical examinations the amount of antigen was evaluated in the lung, liver and spleen and was based on the number of affected organs and antigen observations/field of vision at 100× magnification