Skip to main content

Table 1 Pharmacokinetic parameters of sarafloxacin after a single i.v. and p.o. administration at a dose of 10 mg/kg BW to Muscovy ducks (n = 12) using a non-compartmental model

From: Pharmacokinetic and pharmacodynamic modeling of sarafloxacin against avian pathogenic Escherichia coli in Muscovy ducks

Parameter

Unit

IV

PO

T1/2β

h

6.11 ± 1.97

8.21 ± 2.31

Tmax

h

—

0.44 ± 0.16

Cmax

μg/mL

—

2.03 ± 0.73

AUC0-24 h

μg/mL · h

8.43 ± 1.06

8.26 ± 1.08

VZ

L/kg

10.4 ± 3.32

—

Cl

L/kg · h

1.18 ± 0.16

—

VZ/F

L/kg

—

14.1 ± 3.55

Cl/F

L/kg · h

—

1.21 ± 0.17

MRT0-24 h

h

4.17 ± 1.04

7.75 ± 1.86

F

%

—

97.6 ± 5.32

  1. T 1/2β elimination half-life, AUC area under the curve, T max time for peak concentration, C max peak concentration, V Z /F apparent volume of distribution, Cl/F overall body clearance, MRT mean residence time, AUMC area under the moment curve, F bioavailability