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Table 1 Pharmacokinetic parameters of sarafloxacin after a single i.v. and p.o. administration at a dose of 10 mg/kg BW to Muscovy ducks (n = 12) using a non-compartmental model

From: Pharmacokinetic and pharmacodynamic modeling of sarafloxacin against avian pathogenic Escherichia coli in Muscovy ducks

Parameter Unit IV PO
T1/2β h 6.11 ± 1.97 8.21 ± 2.31
Tmax h 0.44 ± 0.16
Cmax μg/mL 2.03 ± 0.73
AUC0-24 h μg/mL · h 8.43 ± 1.06 8.26 ± 1.08
VZ L/kg 10.4 ± 3.32
Cl L/kg · h 1.18 ± 0.16
VZ/F L/kg 14.1 ± 3.55
Cl/F L/kg · h 1.21 ± 0.17
MRT0-24 h h 4.17 ± 1.04 7.75 ± 1.86
F % 97.6 ± 5.32
  1. T 1/2β elimination half-life, AUC area under the curve, T max time for peak concentration, C max peak concentration, V Z /F apparent volume of distribution, Cl/F overall body clearance, MRT mean residence time, AUMC area under the moment curve, F bioavailability