Fig. 3

Change in monthly seizure frequency (MSF, a) and in monthly cluster days (MCD, b) for each individual animal [%] and estimated % reduction in MSF/MCD with 95% CI. Animals below the lower dotted line (>50% reduction) are responders, animals above the upper dotted line had >50% increase in MSF or MCD. Dogs between the dotted lines (−50% to +50%) had no clinically meaningful change of MSF or MCD. Note, that 8 animals had only clusters during add-on treatment, but not during baseline (open symbols). Four of those had reported clusters in their seizure history, two had seizures on sequential days during baseline, and for two, no seizure history was available