Fig. 2

The effect of C. barometz on the histology (H and E staining) of ethanol-induced stomach mucosa damage in male SD rats. G1 (Normal control group) had intact surface mucosal epithelium with no lesions; G2 (Ulcer control group) had a severe distraction of the surface epithelium and necrotic lesions; G3 (Omeprazole) had a mild distraction of the surface epithelium and reduction in the submucosal edema with inflammatory cells infiltration. The animals pretreated with C. barometz extract in G4 (62.5 mg/kg), G5 (125 mg/kg), G6 (250 mg/kg) and G7 (500 mg/kg) groups revealed a moderate to mild disruption of the surface epithelium, a reduction in submucosal edema and inflammatory cells infiltration in a dose-dependent manner as shown by lowering in or absence of the ulcer area (white arrow), submucosal edema and inflammatory cells infiltration (blue arrow). (Scale bar = 100 μm)