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Fig. 3 | BMC Veterinary Research

Fig. 3

From: H5N2 Highly Pathogenic Avian Influenza Viruses from the US 2014-2015 outbreak have an unusually long pre-clinical period in turkeys

Fig. 3

Histological lesions and immunohistochemical detection of viral antigen in 4-week-old turkeys intranasally inoculated with H5N2 HPAI viruses. Tissues collected at 4 days post-inoculation. Virus antigen is stained in red. Magnifications 40×. a Cerebellum. Vacuolation of the molecular and granular layers of the cerebellum with necrosis of the Purkinge neurons. Inset: viral antigen in neurons and glial cells. b Heart. Focal hyalinization and fragmentation of cardiac myocytes. Inset: viral antigen in cardiac myocytes. c Pancreas. Diffuse pancreatic necrosis. Inset: viral staining in acinar epithelium. d Adrenal gland. Confluent necrosis of corticotrophic and chromaffin cells. Inset: viral antigen in adrenal corticotrophic and cromaffin cells. e Bursa de Fabricious. Lymphoid depletion with apoptosis to necrosis in remaining lymphocytes. Inset: viral antigen in phagocytic c and necrotic cells. f Harderian gland. Viral antigen present in epithelial cells and infiltrating phagocytes. g Nasal gland. Viral antigen present in glandular epithelial cells and infiltrating phagocytes. h Proventriculus. Viral antigen present in glandular epithelial cells

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BMC Veterinary Research

ISSN: 1746-6148

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