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Table 3 Pharmacokinetic model parameters for plasma tulathromycin and milk CP-60,300 concentrations in lactating goats

From: Estimation of tulathromycin depletion in plasma and milk after subcutaneous injection in lactating goats using a nonlinear mixed-effects pharmacokinetic modeling approach

Parameter Description Population mean IIV Bootstrap value 2.5% CI 97.5% CI
V (mL) Volume of distribution for the central compartment 326627 1.072 260011.65 169213.19 369548.19
Cl (mL/h) Central clearance 21109.2 0.184 19214.724 16224.881 22463.998
V2 (mL) Volume of distribution for the peripheral compartment 676758 0.232 721665.92 567400.38 835445.28
Cl2 (mL/h) Clearance between the central and the peripheral compartment 12550.5 0.710 16958.522 11499.469 24340.243
CLmilk (mL/h) Clearance from the central compartment to the milk 882.461 0.121 816.285 686.264 957.191
Ka (1/h) Absorption rate constant after subcutaneous (SC) injection 0.295 6.255 0.938 0.327 2.318
Residue error 1 (%) Proportional error model of tulathromycin concentrations in plasma 0.485 NA 0.484 0.419 0.549
Residue error 2 (%) Proportional error model of CP-60,300 cumulative amounts in milk 0.0234 NA 0.0228 0.0157 0.0279
  1. CI confidence interval, IIV interindividual variability, NA not available