Table 3 Pharmacokinetic model parameters for plasma tulathromycin and milk CP-60,300 concentrations in lactating goats
Parameter | Description | Population mean | IIV | Bootstrap value | 2.5% CI | 97.5% CI |
|---|---|---|---|---|---|---|
V (mL) | Volume of distribution for the central compartment | 326627 | 1.072 | 260011.65 | 169213.19 | 369548.19 |
Cl (mL/h) | Central clearance | 21109.2 | 0.184 | 19214.724 | 16224.881 | 22463.998 |
V2 (mL) | Volume of distribution for the peripheral compartment | 676758 | 0.232 | 721665.92 | 567400.38 | 835445.28 |
Cl2 (mL/h) | Clearance between the central and the peripheral compartment | 12550.5 | 0.710 | 16958.522 | 11499.469 | 24340.243 |
CLmilk (mL/h) | Clearance from the central compartment to the milk | 882.461 | 0.121 | 816.285 | 686.264 | 957.191 |
Ka (1/h) | Absorption rate constant after subcutaneous (SC) injection | 0.295 | 6.255 | 0.938 | 0.327 | 2.318 |
Residue error 1 (%) | Proportional error model of tulathromycin concentrations in plasma | 0.485 | NA | 0.484 | 0.419 | 0.549 |
Residue error 2 (%) | Proportional error model of CP-60,300 cumulative amounts in milk | 0.0234 | NA | 0.0228 | 0.0157 | 0.0279 |