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Table 2 Average concentrations of tulathromycin in plasma and the marker residue CP-60,300 in milk after twice subcutaneous injections of 2.5 mg/kg tulathromycin in lactating goats

From: Estimation of tulathromycin depletion in plasma and milk after subcutaneous injection in lactating goats using a nonlinear mixed-effects pharmacokinetic modeling approach

Time Plasma SD Milk SD Time Plasma SD Milk SD
12 NA NA 1791.4 672.02 360 NA NA 64.3 20.39
24 NA NA 1167.0 264.23 372 NA NA 26.9 8.23
36 NA NA 763.7 226.64 384 NA NA 47.7 16.54
48 NA NA 364.8 109.83 396 NA NA 46.7 18.93
60 NA NA 281.1 103.50 408 NA NA 45.9 16.43
72 NA NA 140.3 30.71 420 NA NA 37.0 15.74
84 NA NA 154.1 45.25 432 NA NA 32.8 10.11
96 NA NA 107.1 23.03 444 NA NA 30.3 10.55
108 NA NA 131.4 39.94 456 NA NA 24.0 7.51
120 NA NA 90.6 23.20 468 NA NA 23.9 7.56
132 NA NA 56.7 15.54 480 NA NA 22.1 10.49
144 NA NA 59.2 14.50 492 NA NA 23.3 14.07
156 NA NA 50.2 9.61 504 NA NA 25.4 12.87
168 NA NA 41.0 11.11 540 NA NA 20.6 6.28
180 152.5 39.03 1392.8 363.32 588 NA NA 12.0 4.25
192 105.8 44.82 1096.9 151.09 636 NA NA 8.3 3.55
204 75.1 36.48 789.3 292.69 684 NA NA 8.0 4.91
216 61.9 20.64 424.9 168.10 732 NA NA 6.5 1.42
228 39.3 19.24 230.1 101.49 780 NA NA 6.0 2.21
240 46.2 18.20 164.0 68.47 828 NA NA 4.1 3.06
252 39.3 10.90 131.2 41.73 876 NA NA 1.9 2.12
264 29.1 12.87 105.3 33.04 948 NA NA 4.1 1.98
276 20.1 8.77 74.7 24.81 1020 NA NA 2.0 2.21
288 22.5 5.94 78.3 21.99 1092 NA NA 0.9 1.66
300 20.0 5.20 91.6 29.83 1164 NA NA 1.5 2.11
312 12.6 4.34 88.9 26.16 1284 NA NA 1.2 1.71
324 11.7 3.66 85.2 28.94 1380 NA NA 0.5 1.40
336 28.5 18.61 68.4 16.72 1452 NA NA 0.0 0.00
348 12.9 5.94 52.5 26.43 1524 NA NA 0.0 0.00
  1. Time time after the first injection (h), Plasma average concentration of tulathromycin in the plasma (ng/mL), Milk average concentration of CP-60,300 in the milk (ng/mL), SD standard deviation, NA not applicable as no sample was taken