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Table 1 Fold change in gene expression of selected immune genes after LPS challenge

From: Activation of innate immune genes in caprine blood leukocytes after systemic endotoxin challenge

  Gene mRNA fold change P   Gene mRNA fold change P
1 h 2 h 5 h 24 h 1 h 2 h 5 h 24 h
Interferon stimulated genes CXCL10 4 85 11 2 <0.001 LPS-pathway TLR4 −2 2 3 1 <0.05
ISG15 2 43 17 4 <0.001 CD14 −4 1 1 1 <0.01
ISG20 1 9 7 3 <0.001 MyD88 −3 1 1 1 <0.05
IFIT1 1 9 3 1 <0.01 TRAF6 1 −2 2 −2 <0.01
OAS1 1 14 7 2 <0.001 IFN-pathway STAT1 1 2 2 1 <0.001
IFI6 1 5 5 3 <0.001 Cytokines and chemokines IL1B 2 2 3 2 <0.01
MX1 1 17 11 2 <0.001 IL8 2 3 2 1 <0.01
Acute phase proteins SAA3 4 80 412 10 <0.001 CCL3 3 2 4 1 <0.001
LF 3 5 17 2 <0.001 CCL5 −4 −3 −1 −5 <0.001
HP 8 14 54 1 <0.001 IL18 −3 −3 −3 1 <0.01
LCN2 2 2 3 −2 <0.01 IL1RN 1 14 7 1 <0.05
Enzymes HSPA1A 1 3 13 1 <0.001 Other immune- related genes TICAM 1 −3 −3 −2 <0.001
S100A9 1 8 18 3 <0.001 ITGB2 −2 −2 4 1 <0.001
SOD2 −3 3 3 1 <0.001 MHCII 1 −2 −3 1 <0.001
  1. Relative gene expression following intravenous LPS (0.1 μg/kg) administration in goats. Fluidigm qPCR was performed on RNA extracted from circulating leukocytes at the indicated time points. Results are expressed as mean fold change relative to baseline samples (0 h) scaled to 1. The most regulated time point for each gene is highlighted in bold, and significance level at this time point is given