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Table 1 Fold change in gene expression of selected immune genes after LPS challenge

From: Activation of innate immune genes in caprine blood leukocytes after systemic endotoxin challenge

 

Gene

mRNA fold change

P

 

Gene

mRNA fold change

P

1 h

2 h

5 h

24 h

1 h

2 h

5 h

24 h

Interferon stimulated genes

CXCL10

4

85

11

2

<0.001

LPS-pathway

TLR4

−2

2

3

1

<0.05

ISG15

2

43

17

4

<0.001

CD14

−4

1

1

1

<0.01

ISG20

1

9

7

3

<0.001

MyD88

−3

1

1

1

<0.05

IFIT1

1

9

3

1

<0.01

TRAF6

1

−2

2

−2

<0.01

OAS1

1

14

7

2

<0.001

IFN-pathway

STAT1

1

2

2

1

<0.001

IFI6

1

5

5

3

<0.001

Cytokines and chemokines

IL1B

2

2

3

2

<0.01

MX1

1

17

11

2

<0.001

IL8

2

3

2

1

<0.01

Acute phase proteins

SAA3

4

80

412

10

<0.001

CCL3

3

2

4

1

<0.001

LF

3

5

17

2

<0.001

CCL5

−4

−3

−1

−5

<0.001

HP

8

14

54

1

<0.001

IL18

−3

−3

−3

1

<0.01

LCN2

2

2

3

−2

<0.01

IL1RN

1

14

7

1

<0.05

Enzymes

HSPA1A

1

3

13

1

<0.001

Other immune- related genes

TICAM

1

−3

−3

−2

<0.001

S100A9

1

8

18

3

<0.001

ITGB2

−2

−2

4

1

<0.001

SOD2

−3

3

3

1

<0.001

MHCII

1

−2

−3

1

<0.001

  1. Relative gene expression following intravenous LPS (0.1 μg/kg) administration in goats. Fluidigm qPCR was performed on RNA extracted from circulating leukocytes at the indicated time points. Results are expressed as mean fold change relative to baseline samples (0 h) scaled to 1. The most regulated time point for each gene is highlighted in bold, and significance level at this time point is given