Treatment |
---|
Parameters | Intravenous | SC | SC-LA |
---|
λ z (1/h) | 0.16 ± 0.07 | 0.14 ± 0.06 | 0.02 ± 0.01 a, b
|
t½λz
1 (h) | 4.21 | 5.10 | 41.12a, b
|
Vss (L/kg) | 0.18 ± 0.05 | -- | -- |
Vz (L/kg) | 0.31 ± 0.14 | -- | -- |
AUC0–24 (μg · h/mL) | 45.51 ± 6.80 | 38.17 ± 6.97 | 85.13 ± 7.53 a
|
AUC0-∞ (μg · h/mL) | 47.06 ± 6.84 | 39.88 ± 6.26 | 117.12 ± 11.54 a
|
MRT (h) | 4.27 ± 0.98 | 6.29 ± 0.35a
| 25.11 ± 4.35 a, b
|
Cl (L/h · kg) | 0.04 ± 0.01 | -- | -- |
MAT (h) | -- | 2.02 ± 1.09 | 20.83 ± 5.13 b
|
Ka (1/h) | -- | 0.53 ± 0.49 | 0.03 ± 0.01 b
|
Cmax (μg/L) | -- | 6.25 ± 0.85 | 7.77 ± 1.26 |
Tmax (h) | -- | 0.91 ± 0.20 | 4.66 ± 2.05 b
|
F (%) | -- | 85.16 ± 10.24 | 84.43 ± 7.40 |
- T½λz: The elimination half-life associated with the terminal slope (λz) of a semilogarithmic concentration-time curve. Vz: The apparent volume of distribution calculated by the area method. Vss: The apparent volume of distribution at steady state. AUC0-∞: The area under the serum concentration-time curve from zero to infinity. AUC0–24: the area under the serum concentration–time curve from zero to 24 h. MRT: Mean residence time. MAT: Mean absorption time. Cl: The total body clearance of drug. Tmax: The time to reach peak concentration following extravascular administration. MAT: Mean absorption time. Ka: Absorption rate constant. Cmax: The peak concentration following extravascular administration. F: The fraction of the administered dose systemically available (bioavailability). aSignificantly different from IV (P < 0.05). bSignificantly different from SC (P < 0.05). 1 Harmonic Mean