Skip to main content

Table 1 Allometric scaling of pharmacokinetics of different cephalosporins in animals

From: Modelling concentrations of antimicrobial drugs: comparative pharmacokinetics of cephalosporin antimicrobials and accuracy of allometric scaling in food-producing and companion animals

Cephalosporin Included animal species Total no. of animals included (n) Pharmacokinetic parameter Allometric coefficient Allometric exponent R2 (R2 including human data) R2 with calculated t½ References
Ceftriaxone Dogs, cats, foals, horses 22 Half-life 1.9820 0.0896 0.0672 0.102 [18, 21, 31, 32]
Volume of distribution 0.9213 0.8044 0.7173  
Clearance 0.4569 0.8854 0.9158  
Ceftazidime Dogs (puppies and adults), cats, cattle, rabbits 34 Half-life 0.7690 0.0768 0.6550 (0.4719) 0.662 Animal + human data [16, 19, 20, 3335]:
Volume of distribution 0.2670 1.0611 0.9829 (0.9773)  
Clearance 0.3158 0.8306 0.9787 (0.9683)  
Ceftiofur Calves, chickens, foals, horses 68 Half-life 3.7440 0.2155 0.4811 0.128 [3641]
Volume of distribution 0.1485 1.3129 0.9875  
Clearance 0.0210 1.2431 0.9552  
Cefquinome Dogs, calves, piglets, chickens, horses, rabbits 51 Half-life 0.8230 0.1389 0.3878 0.243 [22, 4245]
Volume of distribution 0.2604 0.9551 0.9854  
Clearance 0.3032 0.8524 0.9790  
Cefepime Dogs, calves, foals, horses 29 Half-life 0.7337 0.1787 0.6284 0.876 [4649]
Volume of distribution 0.1174 1.1347 0.9783  
Clearance 0.1827 0.8439 0.9725  
  1. For details on pharmacokinetic data, see Additional file 1: Table S1. In the presented results both young and adult animals were included in the allometric analysis. The values reported here are excluding any human data, except for ceftazidime, where allometric analysis was performed both with and without human data