Table 4 In vitro activity of QdNOs in combination with various antibacterials against Mycoplasma gallisepticum
Drug combination | M. gallisepticum PG31 | M. gallisepticum BG44T | ||||
|---|---|---|---|---|---|---|
FICA + FICB | FIC | Combined effect | FICA + FICB | FIC | Combined effect | |
CYA + Tetracycline | 0.25 + 0.5 | 0.75 | additive | 0.25 + 0.5 | 0.75 | additive |
CYA + Doxycycline | 0.5 + 0.5 | 1 | additive | 0.5 + 0.5 | 1 | additive |
CYA + Lincomycin | 0.5 + 0.25 | 0.75 | additive | 0.25 + 1 | 1.25 | indifferent |
CYA + Clindamycin | 0.5 + 0.5 | 1 | additive | 0.25 + 1 | 1.25 | indifferent |
CYA + Danofloxacin | 0.5 + 1 | 1.5 | indifferent | 0.25 + 1 | 1.25 | indifferent |
CYA + Enrofloxacin | 0.25 + 1 | 1.25 | indifferent | 0.25 + 1 | 1.25 | indifferent |
CYA + Tylosin | 0.5 + 0.5 | 1 | additive | 1 + 0.5 | 1.5 | indifferent |
CYA + Kitasamycin | 0.25 + 1 | 1.25 | indifferent | 0.5 + 0.5 | 1 | additive |
QCT + Tetracycline | 0.25 + 0.5 | 0.75 | additive | 0.25 + 0.5 | 0.75 | additive |
QCT + Doxycycline | 0.5 + 0.5 | 1 | additive | 0.5 + 0.5 | 1 | additive |
QCT + Lincomycin | 0.5 + 0.5 | 1 | additive | 0.25 + 1 | 1.25 | indifferent |
QCT + Clindamycin | 0.25 + 1 | 1.25 | indifferent | 0.25 + 1 | 1.25 | indifferent |
QCT + Danofloxacin | 0.25 + 1 | 1.25 | indifferent | 0.5 + 0.5 | 1 | additive |
QCT + Enrofloxacin | 0.25 + 1 | 1.25 | indifferent | 0.25 + 1 | 1.25 | indifferent |
QCT + Tylosin | 0.5 + 0.5 | 1 | additive | 0.25 + 1 | 1.25 | indifferent |
QCT + Kitasamycin | 0.25 + 1 | 1.25 | indifferent | 0.25 + 1 | 1.25 | indifferent |
MEQ + Tetracycline | 0.5 + 0.5 | 1 | additive | 0.25 + 0.5 | 0.75 | additive |
MEQ + Doxycycline | 0.5 + 0.5 | 1 | additive | 0.5 + 0.5 | 1 | additive |
MEQ + Lincomycin | 0.25 + 1 | 1.25 | indifferent | 0.25 + 1 | 1.25 | indifferent |
MEQ + Clindamycin | 0.5 + 0.5 | 1 | additive | 0.25 + 1 | 1.25 | indifferent |
MEQ + Danofloxacin | 0.5 + 1 | 1.5 | indifferent | 0.25 + 1 | 1.25 | indifferent |
MEQ + Enrofloxacin | 0.25 + 1 | 1.25 | indifferent | 0.25 + 1 | 1.25 | indifferent |
MEQ + Tylosin | 0.5 + 0.5 | 1 | additive | 0.25 + 1 | 1.25 | indifferent |
MEQ + Kitasamycin | 0.25 + 1 | 1.25 | indifferent | 0.5 + 0.5 | 1 | additive |