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Table 2 Details of scrapie-affected goats that provided milk and/or had milk tested for PrPsc

From: Evidence of scrapie transmission to sheep via goat milk

Donor Genotype codon 142 Clinical status Post-mortem TSE status (LRS tissue & brain)b CAEV status PrPsc in mammary gland PMCA positive result in milk/ number of tests (days of lactation) Weekly somatic cell count in milk [×103 cells/ ml] (median)
Milk transmission study
 G1472 II 2/10 & N absent 0/2 (1, 10, 19, 29) 1013, 1922, 993, 1514 (1003)
 BIIa II + 7/10 & P absent 0/2 (5, 35); 1/3 (20), 0/3 (51) 878, 3707, 1152, 949, 3469, 1192 (1172)
 G1143 II ± 9/10 & N + present 0/2 (1, 16, 30, 45) 86, 155, 163, 97, 262, 136 (145.5)
 G1427a II 10/10 & N + present 0/2 (6, 22, 47, 66) 956, 2445, 640, 439, 171, 415, 419, 219, 388, 551 (429)
 G1465 IM ± 1/10 & N + absent 0/2 (1, 10, 18, 29) 413, 990, 2140, 978 (984)
 G1415 IM ± 8/10 & P absent 0/2 (1, 20, 39, 59) 1591, 279, 405, 439, 336, 431, 627, 369 (418)
 G1383 IM ± 9/10 & P absent 0/2 (1, 21, 42, 61) 4708, 312, 269, 219, 132, 148, 92, 107 (183.5)
 BIM IM ± 10/10 & P absent 0/2 (1, 21); 1/3 (43); 0/3 (61) 2556, 271, 459, 6133, 267, 84, 347, 225 (309)
PrPsc detection only by sPMCA
 G1376 II 0/10 & N absent 0/2 (1, 10, 29); 0/3 (18) 853, 3420, 205, 3109 (1981)
 G1136 IM 0/10 & N absent 0/2 (1, 9, 18, 29) 354, 565, 378, 531 (454.5)
 G1382 IM 0/10 & N + absent 0/2 (1, 19); 0/3 (10, 29) 135, 4388, 3835, 7007 (4112)
 G1454 IM ± 0/10 & N absent 0/2 (1, 10, 19, 29) 11, 8373, 469, 2808 (1639)
 G1122 MM 0/10 & N absent 0/2 (1, 37, 55); 0/3 (18) 238, 3646, 3586, >10000, >10000, 244, 215, 331 (1959)
 G1115 MM ± 0/10 & N absent 0/2 (1, 19, 37, 56) 48, 325, 535, 322, 300, 108, 198, 340 (311)
  1. aalso provided colostrum
  2. bPost-mortem TSE status was determined by immunohistochemistry as described previously [12] and is shown as number of positive LRS tissues/number examined & PrPsc in brain (P = positive; N = negative). CAEV status was determined serologically
  3. – = clinically unremarkable or negative serology result; ± = inconclusive signs with regards to scrapie; + = clinically affected or positive serology result