Antimicrobial | Dosage regimen (mg/kg) | Cmax (μg/mL) | AUC24h (μg h/mL) | Cmax/MIC90
| Cmax/MPC90
| AUC24/MIC90 (h) | AUC24/MPC90 (h) |
T > MIC90 (h) |
T > MPC90 (h) | %T
MSW
|
---|
Cefquinomea
| 5, IM | 9.38 | 23.78 | 18.76 | 0.15 | 47.56 | 0.37 | ~7.6 | 0 | 31.67 |
Florfenicolb
| 30, IM | 3.24 | 36.42 | 1.62 | 0.10 | 18.21 | 1.14 | ~5.2 | 0 | 21.67 |
-
C
max
serum maximum concentration, AUC
24h
area under curve over a 24 h time period, MIC minimum inhibitory concentration, MPC mutant prevention concentration, T
MSW
time inside the mutant selection window, IM intramuscularly
-
a based on data as published by Yuan et al
-
b based on data as published by EL-Banna