Table 2 Daily dose, duration of lead exposure and clinical findings in dogs given dietary lead experimentally
From: Lead intoxication in dogs: risk assessment of feeding dogs trimmings of lead-shot game
Daily dose and chemical form | Duration | Age and breed (number of dogs) | Clinical and pathological findings | References |
|---|---|---|---|---|
1 mg lead acetate/kg bw/day | 20 weeks | 3 months old hounds (n = 6) | Increased blood pressure and plasma renin activity | [31] |
2 or 5 mg lead acetate/kg bw/day | 13 weeks | 2 months old beagles (n = 4) | Lowered ALA-D activity, increased number of nucleated erythrocytes | [30] |
50 or 100 mg lead carbonate/kg bw/day | 1 week | One year old beagles (n = 2) | Increased hepatic enzyme activity | [38] |
50 mg lead carbonate/kg bw/day | 5 weeks | One year old beagles (n = 2) | Hepatic and renal histological changes, altered hepatic enzyme activity | [38] |
~3 mg lead acetate/kg bw/daya | 12 weeks | 1 month old mongrels (n = 3) | Anemia, cachexia, increased organ weights, hepatic and renal lesions, bone malformation, altered blood chemistry | [24] |