Does canine inflammatory bowel disease influence gut microbial profile and host metabolism?

BMC Veterinary Research

Table 4 Blood parameters of IBD and control dogs. (IBD: n = 15, Control: n = 10)

	Control		IBD		q value
	Mean	SD	Mean	SD	q value
Cobalamin (pmol/L)^a	285	68.1	301	213	0.651
Folate (pmol/L)^b	34.5	6.75	24.0	11.5	0.023
Indoxyl sulfate (mg/dL)	1.56	1.05	1.57	1.65	0.681
Plasma amino acids
Valine (μmol/L)	213	43.1	287	53.8	0.003
Leucine (μmol/L)	257	58.3	274	61.0	0.536
Ornithine (μmol/L)	32.6	7.42	37.7	8.41	0.187
Citrulline (μmol/L)	112	48.1	71.3	39.0	0.016
Citrulline/Ornithine	3.53	1.77	2.00	1.07	0.014
Plasma acylcarnitine profile
C0 (μmol/l)	16.2	13.7	36.1	21.9	0.003
Total acylcarnitines (μmol/L)	2.16	1.03	4.00	1.84	0.003
Total acylcarnitines/C0 (%)	16.4	6.9	12.4	4.7	0.113
C2/C0 (%)	11.0	4.8	7.6	3.6	0.096
C3/C0 (%)	0.587	0.483	0.749	0.796	0.643
C4/C0 (%)	0.606	0.248	0.316	0.149	0.008
C4DC/C0 (%)	0.374	0.172	0.179	0.103	0.006
3OHC4/C0 (%)	0.111	0.083	0.119	0.078	0.874
(C5 + 3OHC5)/Leucine (%)	0.034	0.028	0.060	0.024	0.006

IBD: inflammatory bowel disease; C0: free carnitine, C2: acetylcarnitine, C3: propionylcarnitine, C4: butyrylcarnitine + isobutyrylcarnitine, C4DC: methylmalonylcarnitine, 3OHC4: 3-hydroxybutyrylcarnitine, C5: isovalerylcarnitine + methylbutyrylcarnitine, 3OHC5: 3-hydroxyisovalerylcarnitine + 2-methyl-3-hydroxybutyrylcarnitine
^a Reference range of cobalamin: 73–485 pmol/L. One dog in IBD group is out of reference range
^b Reference range of folate: 9.0–36.0 nmol/L. Five dogs in IBD group and four dogs in control group are out of reference range

ISSN: 1746-6148