Association of anticardiolipin, antiphosphatidylserine, anti-β2 glycoprotein I, and antiphosphatidylcholine autoantibodies with canine immune thrombocytopenia

Table 3 Frequency of antiphospholipid antibodies among different groups of dogs based on the 99^th percentile cut-off

aPL subtype	I/I_A/I_B/I_C ^a	II^b	III^c	I/I_A/I_B/I_C	I/I_A/I_B/I_C
	n = 64/20/18/26	n = 30	n = 80	vs. II	vs. III
	positive (%)	positive (%)	positive (%)	relative risk (odds ratio)^{d, e}	relative risk (odds ratio)
aPhL	63/20/18/25 (98/100/100/96)	26 (87)	2 (3)	3.5 ^/(6.9)/(6.2)/2.4*	76 ^*/(1287)^/(1162)^/73 ^*
aβ₂GPI	49/17/12/20 (77/85/67/77)	16 (53)	2 (3)	1.4^/1.9^/1.4/1.8	30 ^*/24 ^/12 ^/12 ^*
aCL	63/19/18/26 (98/95/100/100)	20 (67)	3 (4)	8.3 ^*/5.3** ^/(19)^/(27)^**	74 ^*/67 ^/(819)^/(1174)^*
aPI	25/8/9/8 (39/40/50/31)	6 (20)	3 (4)	1.3/1.7/2.2/1.3	2.2 ^*/5.3 ^/7.1* ^*/3.8 ^*
aPC	35/12/11/12 (55/60/61/46)	9 (30)	4 (5)	1.3^/2.0* ^/2.2*/1.4	3.2 ^*/7.8 ^/8.7* ^*/4.8 ^*
aPS	45/16/14/15 (70/80/78/58)	13 (43)	4 (5)	1.4^/2.9* ^/2.7* ^*/1.3	4.5 ^*/16 ^/15 ^/6.2 ^*

^aSubgroups of Group I (thrombocytopenia): I_A (immune thrombocytopenia, aPLT⁺, platelet < 30 × 10³/uL), I_B (severe thrombocytopenia, aPLT^-, platelet < 30 × 10³/uL), and I_C (less severe thrombocytopenia, platelet 30 – 80 × 10³/uL). ^bGroup II: outpatient dogs without thrombocytopenia. ^cGroup III: healthy dogs. ^dOdds ratio is shown in parenthesis if relative risk is ∞. ^eValue > 2 is shown in bold. ^*Frequencies are significantly different (^* P < 0.05; ^** P < 0.01; ^*** P < 0.001)

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