Fig. 8
From: Antiproliferative effects of masitinib and imatinib against canine oral fibrosarcoma in vitro
Cell apoptosis following treatment with imatinib and masitinib, alone or combined with doxorubicin. Graphical plot of relative caspase activity following treatment with escalating concentrations of masitinib and imatinib alone (a and b) and doxorubicin combined with 1.0 μM of either masitinib or imatinib (c and d) on MBSa1 and CoFSA cells, respectively. Caspase activity was assessed using a luminogenic caspase-3/7 substrate assay following treatment with the above drug concentrations after 72 h of incubation and expressed as a percentage of caspase activity within vehicle-treated (DMSO 0.1 %) control cells. COS cells treated with SB2224269 represent a positive control. Plotted values are mean ± standard error of the mean. “*” indicates statistically significant (p < 0.001) difference compared to the vehicle-treated controls indicated by a one-way ANOVA with Dunnett’s correction