Fig. 7
From: Antiproliferative effects of masitinib and imatinib against canine oral fibrosarcoma in vitro
Cell viability following PDGFRB siRNA transfection. Effect of PDGFRB siRNA transfection on (a) CoFSA and (b) MBSa1 cell viability assessed via an MTS assay after 72 h of incubation, with representative photomicrographs of cells under each condition (CoFSA cells treated with (c) vehicle alone, d scrambled siRNA sequence, and e PDGFRB siRNA; MBSa1 cells f treated with vehicle alone, g scrambled siRNA sequence, and h PDGFRB siRNA). Scrambled siRNA sequence used to account for nonspecific, off-target effects. “*” indicates statistically significant (p < 0.05) differences in cell viability compared to vehicle-treated controls. Because siRNA transfection was performed during two independent experiments, statistical analysis for these data was performed using the 6 replicates within one representative siRNA experiment. Visual assessment of cellular appearance in PDGFRB siRNA treated samples (e and h) display apoptotic bodies and marked cellular morphologic deterioration