Skip to main content

Table 3 Mutagenicity of dry canine-food extracts from absolute ethanol with S. typhimurium TA98and TA100

From: Thai generic-brand dry canine foods: mutagenicity and the effects of feeding in vivo and in vitro

sample

Amount mg/plate

No. of His+ Revertants/platea

TA 98, -S9

TA 98, +S9

TA100, -S9

TA 100, +S9

DG diet

0

32

30

122

110

 

0.1

30

50

91

86.5

 

0.5

33

41

129

92

 

1

36.5

52

114

90.5

 

5

19p

44

85p

84.5

 

7.5

ND

47e

ND

90.5e

 

10

13.5p

11.5p

ND

76.5p

AP diet

0

28

27

137

110

 

0.01

26.5

ND

116

ND

 

0.1

25

39

116.5

87

 

0.5

29.5

38.5

84.5

90.5

 

1

55

33

61p

87

 

5

25.5p

33.5

76.5p

81

 

10

26p

45.5p

100.5p

103.5e

 

20

31.5p

30p

86p

100e

 

30

21p

ND

105.5p

ND

AL diet

0

28

30

137

110

 

0.01

66

ND

113

ND

 

0.1

63

38.5

94.5

91

 

0.5

64.5p

49

83p

103

 

1

32p

56.5

94.5p

107.5

 

5

ND

31.5p

ND

132.5

 

10

ND

21p

ND

ND

RS diet

0

32

26

137

110

 

0.01

27

ND

ND

ND

 

0.1

48.5

33

196.5

92

 

0.5

31p

42.5

307.5

126

 

1

37.5p

30

262.5

138.5

 

7.5

ND

28.5

63p

87.5p

 

10

ND

ND

75p

106.5p

NT diet

0

32

30

108

110

 

0.1

31.5

34.5

69.5

101.5

 

0.5

28.5

63

78p

84.5

 

1

31

52.5

95.5p

127.5

 

2.5

13.5

33

ND

126

 

5

21e

81p

ND

109e

 

10

13.5p

58p

ND

ND

Positive control

Amount/plate

    

4-NQO

0.2 μg

ND

ND

ND

ND

 

0.4 μg

227.5±3

ND

ND

ND

BAP

5 μg

ND

ND

1430±14

863±75

 

10 μg

ND

459±12

ND

ND

AFB1

0.03 μg

ND

130±21

ND

241±12

  1. a =Mean of duplicate
  2. e=effect
  3. p=partial killing effect
  4. ND = Not determined