BMC Veterinary Research

Table 3 Mutagenicity of dry canine-food extracts from absolute ethanol with S. typhimurium TA98and TA100

From: Thai generic-brand dry canine foods: mutagenicity and the effects of feeding in vivo and in vitro

sample	Amount mg/plate	No. of His⁺ Revertants/plate^a
sample	Amount mg/plate	TA 98, -S9	TA 98, +S9	TA100, -S9	TA 100, +S9
DG diet	0	32	30	122	110
	0.1	30	50	91	86.5
	0.5	33	41	129	92
	1	36.5	52	114	90.5
	5	19^p	44	85^p	84.5
	7.5	ND	47^e	ND	90.5^e
	10	13.5^p	11.5^p	ND	76.5^p
AP diet	0	28	27	137	110
	0.01	26.5	ND	116	ND
	0.1	25	39	116.5	87
	0.5	29.5	38.5	84.5	90.5
	1	55	33	61^p	87
	5	25.5^p	33.5	76.5^p	81
	10	26^p	45.5^p	100.5^p	103.5^e
	20	31.5^p	30^p	86^p	100^e
	30	21^p	ND	105.5^p	ND
AL diet	0	28	30	137	110
	0.01	66	ND	113	ND
	0.1	63	38.5	94.5	91
	0.5	64.5^p	49	83^p	103
	1	32^p	56.5	94.5^p	107.5
	5	ND	31.5^p	ND	132.5
	10	ND	21^p	ND	ND
RS diet	0	32	26	137	110
	0.01	27	ND	ND	ND
	0.1	48.5	33	196.5	92
	0.5	31^p	42.5	307.5	126
	1	37.5^p	30	262.5	138.5
	7.5	ND	28.5	63^p	87.5^p
	10	ND	ND	75^p	106.5^p
NT diet	0	32	30	108	110
	0.1	31.5	34.5	69.5	101.5
	0.5	28.5	63	78^p	84.5
	1	31	52.5	95.5^p	127.5
	2.5	13.5	33	ND	126
	5	21^e	81^p	ND	109^e
	10	13.5^p	58^p	ND	ND
Positive control	Amount/plate
4-NQO	0.2 μg	ND	ND	ND	ND
	0.4 μg	227.5±3	ND	ND	ND
BAP	5 μg	ND	ND	1430±14	863±75
	10 μg	ND	459±12	ND	ND
AFB1	0.03 μg	ND	130±21	ND	241±12

^a =Mean of duplicate
^e=effect
^p=partial killing effect
ND = Not determined

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ISSN: 1746-6148

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