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Table 3 Mutagenicity of dry canine-food extracts from absolute ethanol with S. typhimurium TA98and TA100

From: Thai generic-brand dry canine foods: mutagenicity and the effects of feeding in vivo and in vitro

sample Amount mg/plate No. of His+ Revertants/platea
TA 98, -S9 TA 98, +S9 TA100, -S9 TA 100, +S9
DG diet 0 32 30 122 110
  0.1 30 50 91 86.5
  0.5 33 41 129 92
  1 36.5 52 114 90.5
  5 19p 44 85p 84.5
  7.5 ND 47e ND 90.5e
  10 13.5p 11.5p ND 76.5p
AP diet 0 28 27 137 110
  0.01 26.5 ND 116 ND
  0.1 25 39 116.5 87
  0.5 29.5 38.5 84.5 90.5
  1 55 33 61p 87
  5 25.5p 33.5 76.5p 81
  10 26p 45.5p 100.5p 103.5e
  20 31.5p 30p 86p 100e
  30 21p ND 105.5p ND
AL diet 0 28 30 137 110
  0.01 66 ND 113 ND
  0.1 63 38.5 94.5 91
  0.5 64.5p 49 83p 103
  1 32p 56.5 94.5p 107.5
  5 ND 31.5p ND 132.5
  10 ND 21p ND ND
RS diet 0 32 26 137 110
  0.01 27 ND ND ND
  0.1 48.5 33 196.5 92
  0.5 31p 42.5 307.5 126
  1 37.5p 30 262.5 138.5
  7.5 ND 28.5 63p 87.5p
  10 ND ND 75p 106.5p
NT diet 0 32 30 108 110
  0.1 31.5 34.5 69.5 101.5
  0.5 28.5 63 78p 84.5
  1 31 52.5 95.5p 127.5
  2.5 13.5 33 ND 126
  5 21e 81p ND 109e
  10 13.5p 58p ND ND
Positive control Amount/plate     
4-NQO 0.2 μg ND ND ND ND
  0.4 μg 227.5±3 ND ND ND
BAP 5 μg ND ND 1430±14 863±75
  10 μg ND 459±12 ND ND
AFB1 0.03 μg ND 130±21 ND 241±12
  1. a =Mean of duplicate
  2. e=effect
  3. p=partial killing effect
  4. ND = Not determined