Fig. 4
In vivo antiviral activity of PTD-poMx1 in pigs. Nine four-week-old specific-pathogen-free Large White pigs were randomly assigned to three groups of three pigs. All animals were oro-nasally challenged with the 105TCID50 Shimen strain of CSFV. On the first day post challenge (1dpc), pigs in 1 dose group and 3 doses group were injected 1 mg PTD-poMx1/dose via ear vein, while those in the negative control group (NC group) received normal saline. Pigs in 3 doses group were injected two more times with 1 mg PTD-poMx1 at 3 and 5 dpc. Clinical parameters monitored in experimental groups: a Rectal temperature; b Clinical score; c Pathological lesion; d White blood cell count; e Viral load in sera using qRT-PCR; f Progeny viruses in sera using a TCID50 assay. All data were expressed as the mean (±S.D) of results obtained for the 3 pigs in each group within 3 weeks. Statistical significance was indicated as not significant (ns) (P > 0.05), *(P < 0.05) and **(P < 0.01)