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Table 2 Sample sizes and outcomes for 20 OTP-controlled RCTs

From: Veterinary homeopathy: Systematic review of medical conditions studied by randomised trials controlled by other than placebo

i: Individualised/Treatment
Ref. First author Year N start (hom.) N start (cont.) N start (tot.) N end (hom.) N end (cont.) N end (tot.) % Attrition Designated 'main outcome' Type of data Direction of change favouring homeopathy Problem with designated 'main outcome measure' End-point Notes
A12 Schütte 1988 33 31 64 33 31 64 0.0 Piglet mortality Dichot. Lower Yes: Gives percentage of dead piglets (events) but not number of piglets born (total) 28 d N = No. of sows treated
ii: Non-individualised/Treatment
Ref. First author Year N start (hom.) N start (cont.) N start (tot.) N end (hom.) N end (cont.) N end (tot.) % Attrition Designated 'main outcome' Type of data Direction of change favouring homeopathy Problem with designated 'main outcome measure' End-point Notes
A42 Lohr 2013 53 56 109 46 54 100 8.3 Cure rate (Sum-score (physical condition)) Dichot. Higher Only 46 (Hom) and 54 (Cont) animals regularly completed the study, and are therefore the data for our calculations. The authors themselves calculated cure rate based on 50 and 56 animals respectively. Up to 4 d  
A14 Coelho 2009 35 11 46 35 9 44 4.3 Proportion of animals without diarrhoea at the end of treatment Dichot. Higher No 12 d  
A41 Catto 2013 72 36 108 72 36 108 0.0 Faecal egg count Contin. Lower Yes: Unclear sample sizes – see Notes Second year The numbers of animals in each group based on the assumption that each group comprised 3 paddocks (12 animals in each). No information on dropouts.
A19 Silva 2008 9 9 18 ?9 ?9 ?18 Unclear Mean number of engorged ticks per annum Contin. Lower Yes: SD not stated; N at endpoint not stated 1 yr  
A40 Lotfollahzadeh 2012 52 23 75 50 15 65 13.3 Rectal temperature Contin. Lower   14 d  
A21 Zacharias 2008 7 7 14 ?7 ?7 ?14 Unclear Faecal egg count Contin. Lower No. Numbers for analysis interpolated from Figure 1A. N not stated for endpoint, but assumed to be N = 7. 68 d Disparity between data (mean eggs per gram) for conv med group given in text (1,483) and by inspection of Fig 1 (1,300 approx.)
A15 Faulstich 2006 24 22 46 22 19 41 10.9 Treatment success (overall effectiveness) Dichot. Higher No : Numbers for analysis from percentage data in Table 9 21 d Control really active?
A16 Klocke 2010 32 36 68 32 36 68 0.0 Absence of clinical mastitis infection Dichot. Higher No: Data derived from text of Results [line 6]) First 100 days post-calving  
A20 Varshney 2005 67 96 163 67 96 163 0.0 Quarter cure-rate (non-fibrosed) Dichot. Higher No : Numbers for analysis from percentage data in Table 2 Up to 28 d N = quarters, not animals
A39 Braun 2011 30 34 64 28 32 60 6.3 Cure rate (MMA-sum score) Dichot. Higher   Up to 4 d (H) or 3 d (C)  
A13 Beceriklisoy 2008 30 8 38 30 8 38 0.0 Treatment 'success' (recovery rate) Dichot. Higher No Up to 20 d  
A18 Sandoval 1998 200 200 400 200 200 400 0.0 Cumulative total mortality (1st quality broilers) Contin. Lower Yes: Data are presented as accumulated mortality – not amenable to meta-analysis 49 d N = 1st quality broilers
A17 Rocha 2006 10 10 20 10 10 20 0.0 Proportion of animals not requiring anti-helminthic treatment Dichot. Higher No: Data derived from text of Results (second paragraph) 4 mo (first phase)  
iii: Non-individualised/Prophylaxis
Ref. First author Year N start (hom.) N start (cont.) N start (tot.) N end (hom.) N end (cont.) N end (tot.) % Attrition Designated 'main outcome' Type of data Direction of change favouring homeopathy Problem with designated 'main outcome measure' End-point Notes
A34 Signoretti 2008 8 8 16 ?8 ?8 ?16 Unclear Faecal egg count per gram Contin. Lower No. But assumes zero attrition rate. Data from Table 3. 30 d  
A36 Soto 2008 24 24 48 24 24 48 0.0 Number of animal-days with diarrhoea Dichot. Lower No. But relate 7-day cumulated data to total possible number of animal-days per group 7d period Hom plus sucrose saline vs. sucrose saline only
A31 Reis 2006 30 30 60 30 30 60 0.0 Serum cortisol Contin. Lower No. Assumes zero attrition rate based on legend for Figure 1. 60 d Hom plus mineral salt vs. mineral salt only
A32 Reis 2008 15 15 30 15 ?15 ?30 Unclear Rabies-neutralizing antibody titer Contin. Higher No. But assumes zero attrition rate. 60 d after vaccination Compares Group FEV2 (Hom + salt) with Group V2 (salt only)
A35 Sommer 1972 40 18 58 40 18 58 0.0 Number with infertility disorders Dichot. Lower No. Data from table 2 Not stated  
A38 Williamson 1991 101 32 133 ?100 ?32 ?132 Unclear Number with peripartum disorders Dichot. Lower Yes: Unclear tabulations None  
  1. hom. = homeopathy. cont. = control. tot = total. dichot. = dichotomous. contin. = continuous