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Fig. 3 | BMC Veterinary Research

Fig. 3

From: Inhibition of porcine reproductive and respiratory syndrome virus replication in vitro using DNA-based short antisense oligonucleotides

Fig. 3

Cytopathic effect (CPE) analysis of porcine reproductive and respiratory syndrome virus (PRRSV) in MARC-145 cells transfected with AS-ONs. a. Comparing with the mock treatment, transfection with 50 μM antisense oligonucleotide 5UP2 showed significant cytotoxicity, while transfection with 40 μM did not. b. Four out of nine selected antisense oligonucleotides demonstrated significant (5UP2* and YN8) or moderate (YN4 and YN5) protection from challenge with PRRSV YN-1 strain. Pictures were taken 72 h post infection with a Nikon E5400 camera mounted on an inverted microscope (Nikon TS100)

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BMC Veterinary Research

ISSN: 1746-6148

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