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Table 4 The values of PK/PD parameter and %T > MIC required to achieve various degrees of antibacterial efficacy

From: Response of a clinical Escherichia coli strain to repeated cefquinome exposure in a piglet tissue-cage model

Parameters

Values

E max (△log CFU/mL)

0.09

E 0 (△log CFU/mL)

−0.54

E max - E 0 (△log CFU/mL)

0.63

%T > MIC for 1/6-log drop (%)

3.97

%T > MIC for 1/3-log drop (%)

17.08

%T > MIC for 1/2-log drop (%)

52.68

Slope (N)

1.73

  1. E max, the difference of the bacterial count in the control sample (absence of cefquinome); E 0, the maximum antibacterial effect during 12 h treatment period; N, the Hill coefficient that describes the steepness of the effect curve. %T > MIC, the values of cefquinome required to achieve 1/6-log drop, 1/3-log drop and 1/2-log drop against the clinical E.coli strain during 12 h treatment period
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BMC Veterinary Research

ISSN: 1746-6148

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