Fig. 5
From: Canine mammary cancer cells direct macrophages toward an intermediate activation state between M1/M2
Proliferation of canine mammary carcinoma cells is CSF-1R dependent. Canine mammary carcinoma cell lines, REM134 and Lilly were treated with increasing doses of either CCR2 small-molecule inhibitor (i-iv), toceranib (ii-v), or CSF-1R inhibitor (iii-vi) for 48 h before assaying for cell viability. All experiments are replicates of 3. Asterisks indicate statistically significant differences to the DMSO group, where P < 0.05 by ANOVA