Characterization of a caprine model for the subclinical initial phase of Mycobacterium avium subsp. paratuberculosis infection

Table 6 Study design: group allocation, time point and dose of inoculation and time point of necropsy

Start of inoculation period	3-5 dpn			41-43 dpn
Group	K1	V1	V2	K2	V3	V4
Number of animals (n)	6	7	7	6	6	7
Inoculation dose per day (mg bwm)	-	10	20	-	10	20
Average bacterial counts/mL	-	2.08 ± 0.57x10⁷		-	1.62 ± 0.73x10⁷
Average bacterial counts/inoculum	-	2.08x10⁸	4.16x10⁸	-	1.62x10⁸	3.24x10⁸
Total inoculation dose	-	2.08x10⁹	4.16x10⁹	-	1.62x10⁹	3.24x10⁹
Time of necropsy (wpi)	48^a)	48	49^b)	46	47	48^c)

dpn, days post natum; bwm, bacterial wet mass; wpi, weeks post infection; ^a)one animal was necropsied at 39 wpi; ^b)one animal each died at 37 and 39 wpi, one animal each was necropsied at 37 and 38 wpi; ^c)one animal was necropsied at 35 wpi.

ISSN: 1746-6148