A representative contrast-enhanced ultrasound sequence (A, B, C and D) of a normal left pancreatic lobe in a longitudinal plane after the injection of Sonovue. Each image illustrates contrast enhancement on the left and the grey scale image on the right. (A) The contrast medium is visible in the splenic artery (SA). (B) Microbubbles are still visible in the splenic artery while the pancreatic parenchyma is starting to also receive some contrast material. The splenic vein appears anechoic on the contrast-enhanced image. (C) Homogeneous enhancement of the entire pancreatic lobe at peak enhancement. Some microbubbles are starting to fill the splenic vein (SV). (D) During the wash-out phase, the parenchyma progressively becomes hypoechoic, while the pancreatic vein (SV) reaches its peak in contrast uptake. The contrast medium is also visible in the portal vein (PV).