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Table 1 Isoflurane – mean values with standard deviation

From: Influence of repeated anaesthesia on physiological parameters in male Wistar rats: a telemetric study about isoflurane, ketamine-xylazine and a combination of medetomidine, midazolam and fentanyl

Parameter Run Baseline Induction Non-surgical tolerance Surgical tolerance Wake-up Recovery
  (No. of animals) Mean ± SD Mean ± SD Mean ± SD Mean ± SD Mean ± SD Mean ± SD
SAP (mmHg) 1 (6) 121 ± 11.33 141 ± 13.09 133 ± 15.24 117 ± 7.76 123 ± 12.44 122 ± 11.41
2 (6) 120 ± 11.55 140 ± 10.78 128 ± 16.02 113 ± 9.33 121 ± 10.11 122 ± 10.94
3 (6) 121 ± 7.72 140 ± 11.81 130 ± 12.45 114 ± 8.71 123 ± 8.63 122 ± 8.45
4 (6) 120 ± 13.04 139 ± 12.48 130 ± 12.84 111 ± 9.11 120 ± 12.45 119 ± 9.77
5 (6) 115 ± 18.93 134 ± 16.08 124 ± 18.84 104 ± 16.35* 112 ± 20.32 116 ± 14.24
6 (5) 120 ± 8.00 139 ± 9.83 129 ± 14.88 106 ± 12.51* 120 ± 16.26 121 ± 8.87
DAP (mmHg) 1 (6) 90 ± 7.73 106 ± 11.97 97 ± 12.48 85 ± 6.96 87 ± 11.22 92 ± 7.94
2 (6) 89 ± 10.32 105 ± 10.06 92 ± 14.54 81 ± 7.68 86 ± 7.95 91 ± 8.58
3 (6) 89 ± 6.26 103 ± 10.88 93 ± 9.52 82 ± 7.54 87 ± 5.22 91 ± 7.24
4 (6) 88 ± 9.13 102 ± 10.85 93 ± 9.39 79 ± 6.44 85 ± 7.16 90 ± 8.45
5 (6) 85 ± 11.05 101 ± 9.30 90 ± 10.33 75 ± 7.76* 80 ± 9.46 89 ± 8.00
6 (5) 89 ± 7.55 103 ± 6.26 93 ± 10.85 75 ± 7.84* 84 ± 9.10 91 ± 7.64
MAP (mmHg) 1 (6) 100 ± 8.43 118 ± 11.99 109 ± 13.10 96 ± 6.72 99 ± 11.21 102 ± 8.72
2 (6) 99 ± 10.48 116 ± 9.96 104 ± 14.79 92 ± 7.99 97 ± 8.36 101 ± 9.12
3 (6) 100 ± 6.46 116 ± 10.94 105 ± 10.21 93 ± 7.41 99 ± 5.71 102 ± 7.31
4 (6) 99 ± 10.20 115 ± 11.11 105 ± 10.28 90 ± 6.93 97 ± 8.68 100 ± 8.79
5 (6) 95 ± 13.43 112 ± 11.17 102 ± 12.93 85 ± 10.42* 90 ± 13.00 98 ± 9.86
6 (5) 100 ± 7.28 115 ± 7.01 105 ± 11.92 85 ± 9.16* 96 ± 11.40 101 ± 7.69
PP (mmHg) 1 (6) 32 ± 7.21 35 ± 6.27 36 ± 6.57 32 ± 5.69 35 ± 6.65 30 ± 6.49
2 (6) 31 ± 5.01 35 ± 5.63 35 ± 5.84 32 ± 4.55 35 ± 5.33 30 ± 5.14
3 (6) 32 ± 4.40 37 ± 5.07* 37 ± 5.89 32 ± 6.14 36 ± 6.83 31 ± 4.86
4 (6) 31 ± 6.06 37 ± 5.58* 37 ± 5.99 32 ± 5.72 35 ± 6.88 30 ± 3.14
5 (6) 29 ± 9.60 33 ± 9.24 34 ± 10.02 29 ± 9.63 32 ± 11.29 27 ± 7.66
6 (5) 31 ± 5.37 36 ± 6.44 36 ± 6.82 31 ± 6.47 35 ± 7.82 29 ± 5.18
HR (bpm) 1 (6) 307 ± 27.11 417 ± 37.53 385 ± 22.02 389 ± 20.42 420 ± 22.31 297 ± 16.06
2 (6) 291 ± 16.65 392 ± 33.78 364 ± 18.80* 379 ± 16.73 409 ± 19.53* 297 ± 16.66
3 (6) 295 ± 12.59 393 ± 26.09* 365 ± 15.65* 377 ± 20.73* 411 ± 20.94* 295 ± 11.67
4 (6) 297 ± 25.77 401 ± 28.61 366 ± 20.41* 373 ± 21.72* 407 ± 19.90* 284 ± 12.68*
5 (6) 288 ± 17.14 387 ± 29.30* 358 ± 18.14* 366 ± 16.16* 406 ± 16.86* 291 ± 9.42
6 (5) 298 ± 18.58 386 ± 41.82 352 ± 24.35* 367 ± 7.26* 412 ± 18.68* 289 ± 13.51
BT (°C) 1 (6) 37.62 ± 0.49 37.52 ± 0.50 37.48 ± 0.52 36.50 ± 0.45 36.11 ± 0.52 37.26 ± 0.21
  2 (6) 37.46 ± 0.43 37.43 ± 0.34 37.35 ± 0.33 36.19 ± 0.37 35.71 ± 0.41 37.25 ± 0.16
3 (6) 37.40 ± 0.37* 37.30 ± 0.28 37.20 ± 0.35 36.22 ± 0.35 35.82 ± 0.47 37.19 ± 0.32
4 (6) 37.40 ± 0.37* 37.39 ± 0.22 37.29 ± 0.24 36.32 ± 0.17 35.90 ± 0.37 37.25 ± 0.18
5 (6) 37.46 ± 0.33 37.27 ± 0.29 37.17 ± 0.38 36.16 ± 0.27 35.72 ± 0.30 37.13 ± 0.32
6 (5) 37.56 ± 0.38 37.55 ± 0.25 37.45 ± 0.26 36.20 ± 0.52* 35.71 ± 0.60* 37.20 ± 0.12
  1. *Statistical significant difference (p value ≤ 0.05) based on the ANCOVA with baseline as covariate for the comparison of anaesthetic stages between run 2–6 versus run 1.