Parameter | Run | Baseline | Induction | Non-surgical tolerance | Surgical tolerance | Wake-up | Recovery |
---|---|---|---|---|---|---|---|
 | (No. of animals) | Mean ± SD | Mean ± SD | Mean ± SD | Mean ± SD | Mean ± SD | Mean ± SD |
SAP (mmHg) | 1 (6) | 121 ± 11.33 | 141 ± 13.09 | 133 ± 15.24 | 117 ± 7.76 | 123 ± 12.44 | 122 ± 11.41 |
2 (6) | 120 ± 11.55 | 140 ± 10.78 | 128 ± 16.02 | 113 ± 9.33 | 121 ± 10.11 | 122 ± 10.94 | |
3 (6) | 121 ± 7.72 | 140 ± 11.81 | 130 ± 12.45 | 114 ± 8.71 | 123 ± 8.63 | 122 ± 8.45 | |
4 (6) | 120 ± 13.04 | 139 ± 12.48 | 130 ± 12.84 | 111 ± 9.11 | 120 ± 12.45 | 119 ± 9.77 | |
5 (6) | 115 ± 18.93 | 134 ± 16.08 | 124 ± 18.84 | 104 ± 16.35* | 112 ± 20.32 | 116 ± 14.24 | |
6 (5) | 120 ± 8.00 | 139 ± 9.83 | 129 ± 14.88 | 106 ± 12.51* | 120 ± 16.26 | 121 ± 8.87 | |
DAP (mmHg) | 1 (6) | 90 ± 7.73 | 106 ± 11.97 | 97 ± 12.48 | 85 ± 6.96 | 87 ± 11.22 | 92 ± 7.94 |
2 (6) | 89 ± 10.32 | 105 ± 10.06 | 92 ± 14.54 | 81 ± 7.68 | 86 ± 7.95 | 91 ± 8.58 | |
3 (6) | 89 ± 6.26 | 103 ± 10.88 | 93 ± 9.52 | 82 ± 7.54 | 87 ± 5.22 | 91 ± 7.24 | |
4 (6) | 88 ± 9.13 | 102 ± 10.85 | 93 ± 9.39 | 79 ± 6.44 | 85 ± 7.16 | 90 ± 8.45 | |
5 (6) | 85 ± 11.05 | 101 ± 9.30 | 90 ± 10.33 | 75 ± 7.76* | 80 ± 9.46 | 89 ± 8.00 | |
6 (5) | 89 ± 7.55 | 103 ± 6.26 | 93 ± 10.85 | 75 ± 7.84* | 84 ± 9.10 | 91 ± 7.64 | |
MAP (mmHg) | 1 (6) | 100 ± 8.43 | 118 ± 11.99 | 109 ± 13.10 | 96 ± 6.72 | 99 ± 11.21 | 102 ± 8.72 |
2 (6) | 99 ± 10.48 | 116 ± 9.96 | 104 ± 14.79 | 92 ± 7.99 | 97 ± 8.36 | 101 ± 9.12 | |
3 (6) | 100 ± 6.46 | 116 ± 10.94 | 105 ± 10.21 | 93 ± 7.41 | 99 ± 5.71 | 102 ± 7.31 | |
4 (6) | 99 ± 10.20 | 115 ± 11.11 | 105 ± 10.28 | 90 ± 6.93 | 97 ± 8.68 | 100 ± 8.79 | |
5 (6) | 95 ± 13.43 | 112 ± 11.17 | 102 ± 12.93 | 85 ± 10.42* | 90 ± 13.00 | 98 ± 9.86 | |
6 (5) | 100 ± 7.28 | 115 ± 7.01 | 105 ± 11.92 | 85 ± 9.16* | 96 ± 11.40 | 101 ± 7.69 | |
PP (mmHg) | 1 (6) | 32 ± 7.21 | 35 ± 6.27 | 36 ± 6.57 | 32 ± 5.69 | 35 ± 6.65 | 30 ± 6.49 |
2 (6) | 31 ± 5.01 | 35 ± 5.63 | 35 ± 5.84 | 32 ± 4.55 | 35 ± 5.33 | 30 ± 5.14 | |
3 (6) | 32 ± 4.40 | 37 ± 5.07* | 37 ± 5.89 | 32 ± 6.14 | 36 ± 6.83 | 31 ± 4.86 | |
4 (6) | 31 ± 6.06 | 37 ± 5.58* | 37 ± 5.99 | 32 ± 5.72 | 35 ± 6.88 | 30 ± 3.14 | |
5 (6) | 29 ± 9.60 | 33 ± 9.24 | 34 ± 10.02 | 29 ± 9.63 | 32 ± 11.29 | 27 ± 7.66 | |
6 (5) | 31 ± 5.37 | 36 ± 6.44 | 36 ± 6.82 | 31 ± 6.47 | 35 ± 7.82 | 29 ± 5.18 | |
HR (bpm) | 1 (6) | 307 ± 27.11 | 417 ± 37.53 | 385 ± 22.02 | 389 ± 20.42 | 420 ± 22.31 | 297 ± 16.06 |
2 (6) | 291 ± 16.65 | 392 ± 33.78 | 364 ± 18.80* | 379 ± 16.73 | 409 ± 19.53* | 297 ± 16.66 | |
3 (6) | 295 ± 12.59 | 393 ± 26.09* | 365 ± 15.65* | 377 ± 20.73* | 411 ± 20.94* | 295 ± 11.67 | |
4 (6) | 297 ± 25.77 | 401 ± 28.61 | 366 ± 20.41* | 373 ± 21.72* | 407 ± 19.90* | 284 ± 12.68* | |
5 (6) | 288 ± 17.14 | 387 ± 29.30* | 358 ± 18.14* | 366 ± 16.16* | 406 ± 16.86* | 291 ± 9.42 | |
6 (5) | 298 ± 18.58 | 386 ± 41.82 | 352 ± 24.35* | 367 ± 7.26* | 412 ± 18.68* | 289 ± 13.51 | |
BT (°C) | 1 (6) | 37.62 ± 0.49 | 37.52 ± 0.50 | 37.48 ± 0.52 | 36.50 ± 0.45 | 36.11 ± 0.52 | 37.26 ± 0.21 |
 | 2 (6) | 37.46 ± 0.43 | 37.43 ± 0.34 | 37.35 ± 0.33 | 36.19 ± 0.37 | 35.71 ± 0.41 | 37.25 ± 0.16 |
3 (6) | 37.40 ± 0.37* | 37.30 ± 0.28 | 37.20 ± 0.35 | 36.22 ± 0.35 | 35.82 ± 0.47 | 37.19 ± 0.32 | |
4 (6) | 37.40 ± 0.37* | 37.39 ± 0.22 | 37.29 ± 0.24 | 36.32 ± 0.17 | 35.90 ± 0.37 | 37.25 ± 0.18 | |
5 (6) | 37.46 ± 0.33 | 37.27 ± 0.29 | 37.17 ± 0.38 | 36.16 ± 0.27 | 35.72 ± 0.30 | 37.13 ± 0.32 | |
6 (5) | 37.56 ± 0.38 | 37.55 ± 0.25 | 37.45 ± 0.26 | 36.20 ± 0.52* | 35.71 ± 0.60* | 37.20 ± 0.12 |