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Table 2 Effects of HPTP on liver functions in rats (male and female) in acute toxicity studies

From: Protective effects of (1-(4-hydroxy-phenyl)-3-m-tolyl-propenone chalcone in indomethacin-induced gastric erosive damage in rats

Animals T. protein (g/L) Albumin (g/L) Globulin (g/L) T. billirubin (μmol/L) ALP (IU/L) ALT (IU/L) AST (IU/L)
Male
CMC 0.5% 58.5 ± 2.50 14.0 ± 0.8 45.0 ± 2.0 3.3 ± 0.3 97.5 ± 3.6 55.8 ± 1.5 171.0 ± 5.5
250 mg/kg 53.0 ± 2.6 13.3 ± 1.4 47.5 ± 2.8 4.3 ± 0.5 87.0 ± 8.3 46.5 ± 2.2 183.5 ± 11.2
500 mg/kg 55.8 ± 0.9 14.8 ± 0.6 54.8 ± 2.7 3.3 ± 0.3 101.3 ± 8.1 56.3 ± 3.7 189.3 ± 6.8
1000 mg/kg 55.8 ± 1.1 14.8 ± 1.1 52.8 ± 3.1 4.0 ± 0.4 105.5 ± 6.7 59.3 ± 4.9 176.3 ± 14.5
Female
CMC 0.5% 59.8 ± 1.8 13.0 ± 0.4 42.5 ± 0.9 3.5 ± 0.3 87.5 ± 1.9 55.3 ± 2.8 170.0 ± 4.3
250 mg/kg 58.5 ± 2.5 12.8 ± 1.0 48.0 ± 1.8 4.0 ± 0.4 85.0 ± 3.9 56.0 ± 3.9 189.5 ± 12.7
500 mg/kg 55.0 ± 2.1 15.3 ± 0.6 50.8 ± 3.7 3.8 ± 0.5 93.0 ± 6.4 54.8 ± 2.7 194.5 ± 11.7
1000 mg/kg 55.5 ± 2.3 15.3 ± 0.8 49.0 ± 2.8 3.8 ± 0.5 104.3 ± 4.3 60.0 ± 4.2 215.8 ± 13.0
  1. Values are expressed as Mean ± SEM and One-way ANOVA was used for the analysis.