References | Dewey et al.[18] | Kiviranta et al.[17] | Ruehlmann et al.[35] |
---|---|---|---|
AED evaluated | Pregabalin | Topiramate | Felbamate |
2 nd AED | PB (9 dogs) | PB (10 dogs) | PB (6 dogs) |
3 rd AED | PBr (8 dogs) | PBr (8 dogs) | - |
4 th AED | - | LEV (1 dogs) | - |
No of dogs | 9 | 10 | 6 |
Period of treatment (months) | 3 | 6-15 | median, 9 |
Dose of AED(s) (mg/kg) | Pregabalin: 2 PO TID (dose was increased up to until 3–4 PO TID); PB and PBr: NA but were within normal reference values | TPM: 5 PO BID for 2 m, then 10 PO BID for 2 m and then 10 PO TID for 2 m; PB and PBr and LEV: NA but were within normal reference values | Felbamate: median, 63 (initial dose) and 77 (final dose) PO SID; PB: 3.75 PO BID (stopped 2 m after felbamate started) |
Pre-treatment SF (seizures/month) | median, 4.3; mean, 4.2; range, 2–6.3 (recorded over a period of 3 m) | median, 3.75; range, 2–9 (recorded over a period of 2 m) | median, 3.75 (recorded over a period of median 3.8 m) |
Post-treatment SF (seizures/month) | median 1.7; mean 1.8; range 0.7-3.3 | Range, 4·3 ± 2·5-4· 7 ± 5·0 (recorded at the 6th m) | 2 seizures (in total) |
No of dogs that were failures | - | 3/10 (30%) | - |
No of dogs with >0% - <50% reduction in SF | 2/9 (22%) | 2/10 (20%) | - |
No of dogs with ≥50% - <100% reduction in SF | 7/9 (78%) | 3/10 (30%) | 4/6 (66%) |
No of dogs with 100% reduction in SF | - | 2/10 (20%) | 2/6 (34%) |
No of dogs with >30% reduction in SF | 7/9 (78%) | 6/10 (60%) | 6/6 (100%) |
95% CI successfully treated cases | 51% - 100% | 19% - 81% | 100% |
Overall evidence for/against recommending the use of an AED | Insufficient evidence for recommending the use of pregabalin as an adjunct AED. | Insufficient evidence for recommending the use of topiramate as an adjunct AED. | Insufficient evidence for recommending the use of felbamate as an adjunct AED. |