References | Nafe et al.[25] | Govendir et al.[21] | Platt et al.[22] | |||
---|---|---|---|---|---|---|
AED evaluated | Sodium Valproate | Gabapentin | ||||
2 nd AED | PB (11 dogs) | Primidone (6 dogs) | PB (24 dogs) | - | PB (17 dogs) | PB (11 dogs) |
3 rd AED | Phenytoin (11 dogs) | - | - | - | PBr (16 dogs) | PBr (11 dogs) |
4 th AED | - | - | - | - | - | - |
No of dogs | 11 | 6 | 24 | 16 | 17 | 11 |
Period of treatment (months) | mean, 4.9; range, 1-8 | 4 | 3 | |||
Dose of AED(s) (mg/kg) | range 25–40 PO SID (PB and Phenytoin doses were not reported) | range, 30–45 PO SID; Primidone: NA | range, 30–110 PO SID; PB: NA | range, 25–105 PO SID | median, 35; range, 32–40 PO SID; PB: median, 8; range, 6–12 PO SID; PBr: median, 24; range, 14–30 PO SID | mean, 10.9; 9.3-13.6 PO TID; PB and PBr: NA but were within normal reference values based on the serum levels |
Pre-treatment SF (seizures/month) | mean, 2.7 (period was not recorded) | median, 2; range, 1–4 (recorded over a period of median 1.5 years) | median, 6; 2–140 (recorded over a period of 3 m) | |||
Post-treatment SF (seizures/month) | NA | median, 1; range, 0.5-3 | median, 2; range, 0-4 | |||
No of dogs that were failures | 4/11 (36%) | 3/6 (50%) | 8/24 (34%) | 9/16 (56%) | 6/17 (35%) | 1/11 (9%) |
No of dogs with >0% - <50% reduction in SF | 1/11 (9%) | 2/6 (33%) | 2/24 (8%) | 7/16 (44%) | 1/17 (6%) | 4/11 (36%) |
No of dogs with ≥50% - <100% reduction in SF | 6/11 (55%) | 1/6 (17%) | 14/24 (58%) | 7/16 (44%) | 7/17 (42%) | 6/11 (55%) |
No of dogs with 100% reduction in SF | - | - | - | - | 3/17 (17%) | - |
No of dogs with >30% reduction in SF | 6/11 (55%) | 1/6 (17%) | 14/24 (58%) | 7/16 (44%) | 10/17 (59%) | 9/11 (82%) |
95% CI successfully treated cases | 30% - 84% | −13% - 47% | 38% - 78% | 20% - 68% | 36% - 82% | 26% - 84% |
Overall evidence for/against recommending the use of an AED | Insufficient evidence for recommending the use of sodium valproate either as a monotherapy or an adjunct AED. | Insufficient evidence for recommending the use of gabapentin as an adjunct AED. |