AED evaluated
|
Potassium bromide
|
2
nd
AED
|
-
|
PB (15 dogs) or Primidone (4 dogs)
|
PB (8 dogs) or Primidone (4 dogs)
|
PB or Primidone
|
PB (23 dogs)
|
PB (10 dogs)
|
3
rd
AED
|
-
|
-
|
-
|
-
|
-
|
-
|
4
th
AED
|
-
|
-
|
-
|
-
|
-
|
-
|
No of dogs
|
23
|
19
|
44
|
122
|
37
|
10
|
Period of treatment (months)
|
Approx. 6
|
mean, 21; range, 7-61
|
mean, 7.3 ± 0.6
|
mean, 14.2 +/− 4.7
|
mean, 15; range, 4-33
|
median, 7; mean 7.8
|
Dose of AED(s) (mg/kg)
|
mean, 30.6; range, 26–35 PO BID
|
PBr: 17–58 PO SID;
|
PBr: 40–60 PO SID;
|
Doses were NA but adjusted according to the therapeutic serum levels and clinical response
|
PBr: mean, 20.75; range, 13–40 PO BID; PB: NA
|
PBr: 22 PO SID (dose increases occurred);
|
| |
PB and Primidone: NA but kept at maximum therapeutic doses
|
PB: 6–17 PO SID;
| | |
PB: median, 3.3; mean, 3.8 PO BID (dose was reduced by a mean of 50% in 7/10 dogs during the PBr treatment)
|
| | |
Primidone: 50–70 PO SID
| | | |
Pre-treatment SF (seizures/month)
|
mean, 5.4 +/mean, 14.2 +/−9.7 (recorded over a period of at least 6 weeks)
|
NA (but recorded over period of mean, 31; range, 8–79 m)
|
median, 3 (recorded over a period of mean 1.7 years)
|
NA
|
mean, 14.1 +/− 11.6 (recorded over a period of 0–12 m)
|
median, 27; mean 25; range 3–45 (recorded over a period of 5–72 m)
|
Post-treatment SF (seizures/month)
|
mean, 1.2 +/− 2.4
|
NA
|
median, 1.9
|
-
|
mean, 6.6 +/− 5.7
|
NA
|
No of dogs that were failures
|
3/23 (13%)
|
6/19 (32%)
|
5/12 (42%)
|
-
|
-
|
3/10 (30%)
|
No of dogs with >0% - <50% reduction in SF
|
1/23 (4%)
|
2/19 (10%)
|
2/12 (16%)
|
-
|
6/23 (26%)
|
-
|
No of dogs with ≥50% - <100% reduction in SF
|
5/23 (22%)
|
7/19 (37%)
|
5/12 (42%)
|
88/122 (72%)
|
11/23 (48%)
|
3/10 (30%)
|
No of dogs with 100% reduction in SF
|
12/23 (52%)
|
4/19 (21%)
|
-
|
-
|
6/23 (26%)
|
4/10 (40%)
|
No of dogs with >30% reduction in SF
|
-
|
17/19 (89%)
|
7/12 (32%)
|
88/122 (72%)
|
23/23 (100%)
|
7/10 (70%)
|
95% CI successfully treated cases
|
57% - 91%
|
36% - 80%
|
27% - 57%
|
64% - 80%
|
60% - 88%
|
42% - 98%
|
Overall evidence for/against recommending the use of an AED
|
Fair evidence for recommending the use of potassium bromide as a monotherapy AED.
|
Insufficient evidence for recommending the use of potassium bromide as an adjunct AED.
|