Evaluation of the effects of methadone and tramadol on postoperative analgesia and serum interleukin-6 in dogs undergoing orthopaedic surgery

Table 2 Phisyological parameters measure during time points by treatment group ^#

		Time TBL	point T1	T2	T4	T6	T24
HR	TRA	136 ± 25	123 ± 12	101 ± 25^b	121 ± 25^b	143 ± 25^*,a,b	151 ± 27^a
	MET 0.5	133 ± 25	107 ± 30^*	83 ± 20^*	110 ± 26^b	106 ± 27^*	121 ± 8
	MET 0.7	140 ± 23	117 ± 16	64 ± 17^*	86 ± 26^*	105 ± 17^*	140 ± 14
RR	TRA	56 ± 9	46 ± 11^*	10 ± 2^*	26 ± 13^*	36 ± 18^*	55 ± 10
	MET 0.5	52 ± 13	55 ± 15^*	10 ± 2^*	31 ± 21^*	41 ± 17^*	60 ± 10
	MET 0.7	58 ± 7	60 ± 5^*	10 ± 2^*	25 ± 14^*	39 ± 14^*	52 ± 18
SAP	TRA	183 ± 15	161 ± 17^b	106 ± 17^*	156 ± 25^*	163 ± 24	176 ± 17^a
	MET 0.5	168 ± 24	146 ± 43^b	90 ± 17^*	147 ± 19	147 ± 23	173 ± 10
	Met 0.7	179 ± 23	187 ± 21	98 ± 20^*	120 ± 34	170 ± 23	165 ± 40
MAP	TRA	121 ± 3	128 ± 18	89 ± 19^*	104 ± 28	119 ± 25	140 ± 26
	MET 0.5	126 ± 19	109 ± 31^b	77 ± 13^*	108 ± 23	108 ± 23	123 ± 9
	MET 0.7	134 ± 24	137 ± 18	74 ± 14^*	110 ± 21^*	124 ± 21	122 ± 14
DAP	TRA	91 ± 5	111 ± 5^a	78 ± 17	87 ± 26	92 ± 23	100 ± 5^a
	MET 0.5	100 ± 19	85 ± 28^b	60 ± 12	60 ± 18	87 ± 23	77 ± 12^b
	MET 0.7	106 ± 22	107 ± 18	58 ± 14	84 ± 16	96 ± 21	100 ± 18

^#HR: Heart rate in beats per minute; RR: Respiratory rate in breaths per minute; SAP, MAP and DAP: Systolic, Mean and Diastolic arterial pressures in mmHg.
*:differs from TBL; a: differs from MET 0.5, b: differs from MET 0.7; p < 0.05.

ISSN: 1746-6148