Pharmacokinetic study on pradofloxacin in the dog – Comparison of serum analysis, ultrafiltration and tissue sampling after oral administration

Table 1 Pharmacokinetic parameters (mean ± SD) for enrofloxacin after oral administration (5 mg/kg) in dogs

Parameter	Units	PO Serum	PO ISF
C _max	μg/ml	1.89±0.83	0.59±0.43
AUC ₂₄	h*μg/ml	7.42±3.03	5.19±4.32
AUC _inf	h*μg/ml	7.59±3.09	7.54±3.89
T _max	h	1.66±0.52	5.33±2.31
T _1/2	h	3.18±1.5	4.47±0.42
T ₂₄	h	20±6.92	16±6.92
λ _z	/h	0.26±0.11	0.16±0.02
MRT _last	h	3.70±0.55	7.30±1.14
MRT _inf	h	4.04±0.58	8.25±0.79

C_max maximum concentration; AUC₂₄ area under the curve from time 0 to 24 hours; MRT_last mean residence time; λ_z first order rate constant of terminal portion of the curve; T_1/2 half-life; T_max time to maximal concentration; T ₂₄ time of final measurement; AUC_inf area under the curve from 0 extrapolated to infinity; MRT_inf mean residence time from time 0 extrapolated to infinity for non-infusion models.

ISSN: 1746-6148