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Table 3 Comparison of rabies viral antigen and RNA in major CNS regions in canine paralytic rabies

From: Reduced viral burden in paralytic compared to furious canine rabies is associated with prominent inflammation at the brainstem level

  Spinal cord Brainstem Cerebellum Cerebral midline Cerebrum
  (Mean ± SD) P value (Mean ± SD) P value (Mean ± SD) P value (Mean ± SD) P value (Mean ± SD) P value
% RABV antigen-positive neurons           
Spinal cord 75.19 ± 14.14    0.228   0.090   0.026   0.012
Brainstem   0.228 59.8 ± 36.94    0.201   0.104   0.047
Cerebellum   0.090   0.201 50.8 ± 30.78    0.124   0.047
Cerebral midline   0.026   0.104   0.124 29.53 ± 29.86    0.337
Cerebrum   0.012   0.047   0.047   0.337 18.95 ± 17.16  
% RABV antigen area in positive neuron           
Spinal cord 5.14 ± 0.92    0.148   0.013   0.013   0.013
Brainstem   0.148 3.29 ± 2.58    0.201   0.104   0.265
Cerebellum   0.013   0.201 1.87 ± 1.06    0.201   0.201
Cerebral midline   0.013   0.104   0.201 1.39 ± 1.13    0.265
Cerebrum   0.013   0.265   0.201   0.265 2.09 ± 1.65  
% RABV antigen-positive area per neuron           
Spinal cord 4.03 ± 0.28    0.089   0.013   0.013   0.013
Brainstem   0.089 2.74 ± 2.51    0.147   0.071   0.104
Cerebellum   0.013   0.147 1.18 ± 0.71    0.201   0.104
Cerebral midline   0.013   0.071   0.201 0.69 ± 0.88    0.500
Cerebrum   0.013   0.104   0.104   0.500 0.70 ± 0.69  
RABV RNA (copies/μg total RNA) × 108           
Spinal cord 1.12 ± 1.26    0.148   0.441   0.228   0.441
Brainstem   0.148 2.27 ± 2.11    0.174   0.377   0.087
Cerebellum   0.441   0.174 1.52 ± 1.67    0.174   0.458
Cerebral midline   0.228   0.377   0.174 2.99 ± 2.78    0.125
Cerebrum   0.441   0.087   0.458   0.125 0.83 ± 0.77  
  1. Underlined P values indicate significant difference.