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Table 1 Mean (±SD) ivermectin pharmacokinetic parameters obtained after the intraruminal administration of the Reference (RF), Test 1 (T1) and Test 2 (T2) formulations at 200 μg/kg in nematode infected lambs (n=8)

From: Relative bioavailability and comparative clinical efficacy of different ivermectin oral formulations in lambs

Parameters Reference Test 1 Test 2 P value
Cmax (ng/mL) 5.14 ± 2.46 5.82 ± 2.53 4.96 ± 1.21 0.776
Tmax (days) 0.81 ± 0.26 0.71 ± 0.27 0.60 ± 0.22 0.341
AUC0-LOQ (ng.days/mL) 6.92 ± 3.26 9.18 ± 5.20 8.11 ± 3.27 0.568
AUC0-∞ (ng.days/mL) 7.20 ± 3.23 9.39 ± 5.20 8.35 ± 3.29 0.588
AUC0-LOQ/AUC0-∞ 0.96 [3.9%] 0.98 [2.3%] 0.97 [2.9%] -
MRT (days) 1.61 ± 0.24 1.60 ± 0.40 1.75 ± 0.39 0.724
T1/2el (days) 1.07 ± 0.35 0.90 ± 0.21 1.12 ± 0.45 0.492
Cmax/AUC0-LOQ 0.74 ± 0.13 0.67 ± 0.22 0.64 ± 0.12 0.542
CLʎ /F (L/days) 32.3 ± 12.2 25.6 ± 10.2 27.3 ± 10.9 0.505
Vdarea/F (L/days) 48.5 ± 19.5 32.4 ± 13.5 40.5 ± 13.2 0.189
  1. Cmax: peak plasma concentration; Tmax: time to peak plasma concentration; AUC0-LOQ: area under the concentration vs. time curve form 0 up to the limit of quantification; AUC0-∞: area under the concentration vs. time curve extrapolated to infinity; MRT: mean residence time; T1/2el: elimination half-life. CLƛ /F: apparent total body clearance; Vdarea/F: apparent volume of distribution (area method). Vdarea and CLƛ represent their true values divided by the systemic availability (F) of either drug. In values within a row no statistical differences were observed (P> 0.05). The percentage that AUC0-LOQ differs from AUC0-∞ is reported in bracket [].