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Table 1 Mean (±SD) ivermectin pharmacokinetic parameters obtained after the intraruminal administration of the Reference (RF), Test 1 (T1) and Test 2 (T2) formulations at 200 μg/kg in nematode infected lambs (n=8)

From: Relative bioavailability and comparative clinical efficacy of different ivermectin oral formulations in lambs

Parameters

Reference

Test 1

Test 2

P value

Cmax (ng/mL)

5.14 ± 2.46

5.82 ± 2.53

4.96 ± 1.21

0.776

Tmax (days)

0.81 ± 0.26

0.71 ± 0.27

0.60 ± 0.22

0.341

AUC0-LOQ (ng.days/mL)

6.92 ± 3.26

9.18 ± 5.20

8.11 ± 3.27

0.568

AUC0-∞ (ng.days/mL)

7.20 ± 3.23

9.39 ± 5.20

8.35 ± 3.29

0.588

AUC0-LOQ/AUC0-∞

0.96 [3.9%]

0.98 [2.3%]

0.97 [2.9%]

-

MRT (days)

1.61 ± 0.24

1.60 ± 0.40

1.75 ± 0.39

0.724

T1/2el (days)

1.07 ± 0.35

0.90 ± 0.21

1.12 ± 0.45

0.492

Cmax/AUC0-LOQ

0.74 ± 0.13

0.67 ± 0.22

0.64 ± 0.12

0.542

CLʎ /F (L/days)

32.3 ± 12.2

25.6 ± 10.2

27.3 ± 10.9

0.505

Vdarea/F (L/days)

48.5 ± 19.5

32.4 ± 13.5

40.5 ± 13.2

0.189

  1. Cmax: peak plasma concentration; Tmax: time to peak plasma concentration; AUC0-LOQ: area under the concentration vs. time curve form 0 up to the limit of quantification; AUC0-∞: area under the concentration vs. time curve extrapolated to infinity; MRT: mean residence time; T1/2el: elimination half-life. CLƛ /F: apparent total body clearance; Vdarea/F: apparent volume of distribution (area method). Vdarea and CLƛ represent their true values divided by the systemic availability (F) of either drug. In values within a row no statistical differences were observed (P> 0.05). The percentage that AUC0-LOQ differs from AUC0-∞ is reported in bracket [].
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BMC Veterinary Research

ISSN: 1746-6148

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