Figure 1

Individual plasma concentrations of cimicoxib (ng/mL) vs. time (h) after a single oral administration of cimicoxib (2 mg/kg) in 12 beagle dogs. Visual inspection of the figure suggests the existence of 2 subgroups of dogs which were named “Poor Metabolizers” (red dotted line) and “Extensive Metabolizers” (blue continuous line) (see the text for explanation). Pink squares were female dogs and blue circles male dogs. Letters indicates names of dogs.