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Table 3 PK parameters of enrofloxacin in grass carp (n = 5)

From: Integrated pharmacokinetics/pharmacodynamics parameters-based dosing guidelines of enrofloxacin in grass carp Ctenopharyngodon idella to minimize selection of drug resistance

Tissues Parameters

Dose

10 mg/kg

20 mg/kg

30 mg/kg

 

Serum

Liver

Muscle

Kidney

Serum

Liver

Muscle

Kidney

Serum

Liver

Muscle

Kidney

A(μg/mL)

0.844

3.007

3.334

1.109

1.707

9.072

4.630

7.162

3.904

14.577

2.269

6.154

B(μg/mL)

0.500

1.634

1.025

0.164

1.6

4.631

0.758

3.682

3.013

5.887

1.365

4.044

A(/h)

0.114

0.087

0.022

0.027

0.166

0.191

0.055

0.024

0.164

0.068

0.066

0.044

B(/h)

0.016

0.005

0.159

0.025

0.015

0.015

0.003

0.063

0.007

0.004

0.005

0.036

Ka(/h)

0.491

0.275

0.266

0.478

0.671

1.787

0.216

0.764

0.502

1.445

0.211

0.676

Kel(/h)

0.037

0.020

0.013

0.027

0.024

0.019

0.160

0.024

0.015

0.013

0.143

0.024

T1/2α(h)

6.098

0.080

3.126

25.938

4.186

36.262

12.595

28.344

4.348

10.145

10.515

27.775

T1/2β(h)

42.728

86.253

95.070

42.375

46.757

110.452

150.884

107.861

97.363

184.996

161.381

124.271

Tmax(h)

1.000

1.000

48.000

1.000

0.500

0.500

16.000

0.500

0.500

0.500

10.000

0.500

MRT0-t(h)

44.566

62.765

63.938

55.871

51.841

63.093

67.096

56.620

144.573

65.005

68.159

56.620

Cmax (μg/mL)

2.837

8.941

1.320

3.362

5.685

18.344

2.369

8.152

7.151

20.076

2.628

9.587

AUC24 (μg/mL·h)

25.838

66.108

21.683

33.183

67.585

114.168

40.349

49.589

90.486

242.313

44.666

66.359

AUC (μg/mL·h)

72.538

210.118

129.154

102.899

171.984

338.316

175.160

127.511

318.187

425.763

188.914

181.293

CLs (L/kg·h)

0.155

0.030

0.054

0.080

0.100

0.029

0.095

0.108

0.067

0.020

0.124

0.122

  1. A(μg/mL), Intercept of the linear equation on log transformed data; B(μg/mL), Slope of the linear equation on log transformed data; α(/h), Distribution rate constant; β(/h), Elimination rate constant; Ka(/h), Absorption rate constant; Kel(/h), elimination rate constant from the central compartment; T1/2α(h), Half-life of distribution; T1/2β(h), Half-life of elimination; Tmax(h), Time required to reach Cmax in the interval; MRT0-t(h), Mean residue time of drug in body from zero to 168h; Cmax(μg/mL), Maximum concentration in the interval; AUC24(μg/mL·h), Area under the drug concentration-time curve from the time zero to 24h; AUC(μg/mL·h), Area under the drug concentration-time curve from the time zero to last time point; CLs(L/kg·h), total body clearance.
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BMC Veterinary Research

ISSN: 1746-6148

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