Table 8 Semiquantitative scoring systems for murine models of eye, skin and miscellaneous diseases
Disease model | Scoring system: parameters (scale width) | Citations |
|---|---|---|
Skin diseases | ||
Burn scars [125] | Epidermal hyperplasia/hyperkeratosis, hair follicles, apocrine glands, smooth muscles, fibroplasia, vascular proliferation (each 0,1), collagen orientation (0–3) | 26 |
Systemic sclerosis [126] | Dermal inflammation, thickened collagen bundles, dermal thickness (each 0–3) | 18 |
Atopic dermatitis [127] | Epidermal hypertrophy, hyperkeratosis, parakeratosis, erosion, inflammation, edema, ulcer (each 0–4) | 8 |
UV radiation-induced skin damage [128] | Epidermal thickness (0–3), dermal cellularity (0–3), dermal cyst changes (0–5) | 7 |
Epithelial irritation [129] | Leukocyte infiltration (0–5), epithelial reaction (0,1) | 1 |
Psoriasis [123] | Munro abscesses (1.5), hyperkeratosis (0.5), parakeratosis (1), length of rete ridges (0.5–1.5), lack of granular layer (1), acanthosis (1), dermis lymphocytic infiltrate (0.5–1.5), papillary papillae congestion (1), thinning above papillae (0.5) | 18 |
Psoriasis [124] | Epidermal thickness, Stratum corneum thinning, extent of Stratum granulosum/parakeratosis/inflammation, microabscesses (each 0–3) | 5 |
Ocular diseases | ||
Diabetic retinopathy [130] | Inflammation (leukocytes/100 μm retina length), leukostasis (leukocytes per vessel lumen) | 25 |
Oxygen induced retinopathy [131] | Blood vessel growth, tufts, tortuosity, extraretinal neovascularization, vasoconstriction (each 0–3), hemorrhage (0,1) | 48 |
Bacterial endophthalmitis [132] | Inflammation, retinal architecture (each 0–4), | 18 |
Autoimmune uveoretinitis [133] | Infiltration (0–4) | 285 |
Endotoxin uveitis [134] | Inflammation (0–3) | 47 |
Miscellaneous diseases | ||
Abdominal adhesion [135] | Inflammation, fibrosis, necrosis/abscess, granulomas (each 0–3) | 100 |
Abdominal adhesion [136] | Vessel number, neutrophil infiltration, neutrophils at site (each 0–3) | 4 |
Abdominal adhesion [137] | Fibrotic matrix, collagen fibers, fibroblast proliferation (together 1–5) | n.r. |
Embryonic development [138] | Grading (0–5) of 17 parameters | 429 |
Wound healing [139] | Infiltration, granulation tissue, fibroblasts, collagen deposition (together 0–12) | 369 |
Thyroiditis [140] | Number of inflammatory foci, parenchymal destruction (together 0–4) | 77 |
Vaginitis [141] | Epithelial disruption, leucocyte infiltration, edema, vascular injection (each 0–4) | 74 |
Esophagitis [142] | Epithelial damage/hemorrhage (0–4), inflammation (0–3) | 6 |
Lymph node [143] | Heterophils, apoptotic histiocytes, sinus histiocytosis, follicular hyperplasia (together 0–5) | 1 |
Spermatogenic activity [144] | Presence of spermatozoa/spermatides/germ cells/sertoli cells (together 0–10) | n.r. |