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Table 3 Comparison of pharmacokinetic parameters of common NSAIDS in llamas

From: Bioavailability and pharmacokinetics of oral meloxicam in llamas

 

IV dosages (mean values)

PO dosages (mean values)

Parameter (Units)

Meloxicam (present study)

Phenylbutazone[8]

Ketoprofen[7]*

Flunixin meglumine[6]

Meloxicam (present study)

Phenylbutazone[8]

   

S

R

Sum

   

AUC (hr*μg/mL)

43.96

80.1

168.9

176.4

345.3

49.0

68.35

60.8

Cl (mL/min/kg)

0.190

1.11

0.22

0.21

0.43

0.78

N/A

N/A

T MAX (hr)

N/A

N/A

N/A

N/A

21.4

4.37

T ½ λz (hr)

17.4

2.03

5.49

5.41

5.45

1.47

22.7

7.09

Vss (L/kg)

0.235

0.155

0.100

0.095

0.195

0.030

N/A

N/A

Dose (mg/kg)

0.50

5.0

2.2

2.2

4.4

2.2

1.0

5

F (%)

N/A

N/A

 

N/A

 

N/A

76.0

69.9

  1. * For the ketoprofen study, a racemic mixture of S and R enantomers were administered to each animal. PK values from each enantomer as well as the sum (or in the case of half –life, average) of both are reported here.
  2. AUC = area under the curve extrapolated to infinity; Cl = plasma clearance; TMAX; = time to CMAX; T ½ λz = terminal half-life; Vss = volume of distribution at steady state; F = fraction of the dose absorbed.
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BMC Veterinary Research

ISSN: 1746-6148

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