|
Treatment
| | |
Day
| | |
|---|
|
0
|
21
|
42
|
60
|
90
|
|---|
|
I. Control
|
13 ± 2
|
12 ± 3
|
14 ± 3
|
16 ± 4
|
15 ± 3
|
|
II. Melatonin Implant
|
12 ± 2
|
16 ± 3
|
14 ± 4
|
13 ± 3
|
15 ± 2
|
|
III. Vaccine
|
16 ± 3
|
40 ± 6*†
|
90 ± 5*†
|
104 ± 4*†
|
70 ± 5*†
|
|
IV. Vaccine + Melatonin Implant
|
14 ± 3
|
52 ± 5*†§†
|
112 ± 6*†§†
|
141 ± 5*†§†
|
97 ± 4*†§†
|
- Values represent mean antibodies levels as determined by microagglutination assays. Data are presented as mean ± S.E.M. of 10 experiments. *P < 0.05 compared with day 0. †P < 0.05 compared with their respective control in nonvaccinated animals. §P < 0.05 compared with the application of melatonin implants. †P < 0.05 compared with vaccinated animals.
